“A punch biopsy at the border of the lesion is necessary to rule out melanosis secondary to malignant melanoma that manifests as a generalized blue-gray skin discoloration.”
“It is also an effective, if not necessary, agent to ensure melanosis or black spot does not occur on raw unpeeled shrimp.”
“In chronic cases the eventual effects are anaemia, melanosis, enlargement of the spleen and liver, and general cachexia.”