| It is extremely difficult to prove that a malignant melanoma originates in a visceral site. |
| Any mole that is suggestive of melanoma requires an excisional biopsy, primarily because prognosis and treatment are based on tumor thickness. |
| Patients with melanoma require close follow-up because they are at risk for recurrence and diagnosis of a second primary tumor. |
| The most predictive features for melanoma development are a history of change in an existing nevus or a new and changing pigmented lesion. |
| She had beaten off the disease five years ago after a melanoma had been found on her leg. |
| Malignant melanoma can also affect the choroid of the eye, the layer just under the retina. |
