| Oral intake of tobacco by chewing also increased the excretion as nicotine can be absorbed from oral mucosa. |
| Metabolism of xenobiotics by CYP450s usually reduces the toxicity and promotes excretion of these xenobiotics. |
| In addition, waste materials cannot be transported properly to the lungs and kidneys for excretion. |
| Increased bone resorption, increased gastrointestinal absorption of calcium, and decreased renal excretion of calcium cause hypercalcemia. |
| Treatment with multiple doses of activated charcoal increases the excretion of a number of drugs. |
| In most cases of gout decreased urinary excretion of urate is the most common metabolic abnormality. |
