| These phenotypic classes are discussed below, with reference to previously identified zebrafish melanocyte mutants. |
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| It is characterized by areas of melanocyte proliferation, and the hyper pigmentation of the epidermal basal cell layer in a linear fashion. |
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| Coat colour, an important consideration for many owners, is easily dealt with by picking the right pattern of melanocyte cells in the skin. |
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| With age, melanocyte dysfunctions lead to the appearance of brown spots due to localized hyperpigmentation. |
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| Each melanocyte, via its dendrites, supplies melanin to neighbouring keratinocytes. |
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| A melanocyte can supply melanin to 35-40 keratinocytes. |
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| Each epidermal melanocyte is associated with a group of neighbouring keratinocytes into which it transfers granules of pigment by way of long, branching dendrites. |
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| Melanin-blocking action «locks» melanin synthesis inside the melanocyte. |
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| An audience member asked about the possibility of melanocyte proliferation. |
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| In the very latest model of skin equivalent 'art', researchers can control the number of melanocyte seeds, allowing them to define the skin colour in response to the needs of different populations. |
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| In lentigo maligna, the most frequent cell type is a spindled hyperchromatic melanocyte with scant cytoplasm. |
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| An important and new therapeutic concept for melanoma is to target the melanocyte lineage. |
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| The mutations in melanoma cells occurred in parts of the melanocyte genome that are normally turned off. |
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| The existence of atypical melanocytes on the mucosa surrounding the tumour supports the ectopic melanocyte theory. |
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| Human placental extract, in vivo and in vitro assessments of its melanocyte growth and pigment-inducing activities. |
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| Hydroquinone products take 4 to 6 weeks to show an effect because the agent needs time to penetrate the skin and alter melanocyte metabolism. |
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| Previous studies show that the substance, called alpha melanocyte stimulating hormone, or alpha-MSH, has anti-inflammatory properties. |
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| It then must bind a specific sequence of DNA located in a gene called the KIT ligand oncogene, which stimulates melanocyte production, causing the skin to tan. |
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| Excessive melanin production occurs in melasma, lentigo, nevocellular nevi and malignant melanoma, whereas the loss of melanocyte function leads to vitiligo. |
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| In order to lead active ingredients directly to the melanocyte, the heart of the targeted zone, these ingredients have been encapsulated in Spherulites. |
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