What is another word for hub?

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The effective center of an activity, region, or network
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“In this model, the city serves as a hub for the civic work of these entities and its own agencies.”
The central part of a wheel from which the spokes radiate
“The hub of the wheel is also the largest single steel casting ever made.”
The point at or around the centre of a period of time, activity, etc
The main or greater part of something as distinguished from its subordinate parts
An assemblage or collection of related things
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