| This is performed largely by the enzyme plasmin, generated from its inactive precursor, plasminogen. |
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| Within the fibrinolytic system, plasmin is generated from plasminogen by tissue plasminogen activator, which upon activation lyses fibrin clots. |
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| Plasminogen activators attached to fibrin activate plasminogen, causing the release of the enzyme plasmin within clots and thrombi. |
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| Tissue plasminogen activator and, to a lesser degree, urokinase are serine proteases which convert plasminogen to plasmin. |
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| All of these agents convert plasminogen to plasmin, which in turn breaks down fibrin and promotes clot lysis. |
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| Degradation of fibrin clots is the function of plasmin, a serine protease that circulates as the inactive proenzyme, plasminogen. |
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| Fibrin degradation means that thrombin must have been present to form fibrin and plasmin was present to proteolytically digest it. |
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| They act by stopping the activity of an enzyme, called plasmin, which dissolves blood clots. |
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| The data revealed that FXa and FVa accelerate the production of the fibrinolysis protease plasmin, through a feedback-controlled mechanism. |
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| The broad spectrum serine protease plasmin is formed following cleavage of the zymogen precursor plasminogen by host activators tissue plasminogen activator and urokinase. |
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| An overdose of streptokinase may lead to bleeding from systemic fibrinogenolysis, which is the breakdown of the coagulation factors by plasmin. |
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| If formed in the circulating blood, plasmin is normally inhibited by a circulating plasmin inhibitor. |
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| When tenecteplase activates plasminogen, it converts into plasmin, which breaks down the fibrin mesh that binds the clot together. |
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| The enzymes u-PA and t-PA are responsible for the activation of plasminogen to plasmin, which breaks down blood clots in the vasculature. |
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| Use of a plasmin inhibitor for the manufacture of a pharmaceutical preparation for the treatment of corneal lesions. |
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| A complex of staphylokinase and either plasminogen or plasmin for use in medicine. |
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| Tranexamic acid is an antifibrinolytic agent that competitively inhibits the activation of plasminogen to plasmin. |
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| The fibrinolytic system involves a series of enzymatic reactions that results in the conversion of the proenzyme, plasminogen, into the trypsin-like lyric enzyme, plasmin. |
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| Alteplase is a serine protease that binds to fibrin in a thrombus or blood clot resulting in conversion of plasminogen to plasmin and initiation of local fibrinolysis. |
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| At the same time, plasmin irreversibly inhibits the coagulation activity of prothrombinase. Studies are being conducted to further understand how these newly discovered functions may contribute to normal clot production. |
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| The fibrinolytic system contributes to inflammation primarily through the formation of plasmin, which breaks down fibrin into products that affect vascular permeability. |
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| The active enzyme involved in the fibrinolytic process is plasmin, which is formed from its precursor, plasminogen, under the influence of an activating factor released from endothelial cells. |
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| An elevation in the level of circulating plasmin due to excessive activation of the fibrinolytic system may result in fibrinogenolysis and hemorrhage. |
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| The four are immunoglobulin, haptoglobin, plasmin and cholinesterase blood products made in the 1970s and 1980s by now-defunct drug maker Green Cross Corp. |
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| Once activated, plasmin breaks down fibrin, resulting in the formation of D-dimer, a fibrin degradation product and a clinical marker of fibrinolysis. |
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| Microplasmin is a truncated form of the natural human protein plasmin. |
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| In these conditions, D-dimer, an end-stage product of fibrin degradation by plasmin, is increased as a result of fibrinolysis, but it does not result from fibrinogenolysis. |
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| Plasmin is involved in the destruction of the extracellular matrix which is rich in fibrin. |
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| Plasmin hydrolyzes the casein in milk, causing proteolysis that leads to poor quality in milk products. |
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