| This is performed largely by the enzyme plasmin, generated from its inactive precursor, plasminogen. |
| All of these agents convert plasminogen to plasmin, which in turn breaks down fibrin and promotes clot lysis. |
| Fibrin degradation means that thrombin must have been present to form fibrin and plasmin was present to proteolytically digest it. |
| Degradation of fibrin clots is the function of plasmin, a serine protease that circulates as the inactive proenzyme, plasminogen. |
| Within the fibrinolytic system, plasmin is generated from plasminogen by tissue plasminogen activator, which upon activation lyses fibrin clots. |
| Plasminogen activators attached to fibrin activate plasminogen, causing the release of the enzyme plasmin within clots and thrombi. |
