This is performed largely by the enzyme plasmin, generated from its inactive precursor, plasminogen. |
Tranexamic acid is an antifibrinolytic agent that competitively inhibits the activation of plasminogen to plasmin. |
When tenecteplase activates plasminogen, it converts into plasmin, which breaks down the fibrin mesh that binds the clot together. |
Tissue plasminogen activator and, to a lesser degree, urokinase are serine proteases which convert plasminogen to plasmin. |
Degradation of fibrin clots is the function of plasmin, a serine protease that circulates as the inactive proenzyme, plasminogen. |
An overdose of streptokinase may lead to bleeding from systemic fibrinogenolysis, which is the breakdown of the coagulation factors by plasmin. |