How to use mutant in a sentence

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Sentence Examples These mutant pupae have defects including shortened or bent legs, bristle defects, a split notum, and wing abnormalities. We then compared the double mutant and deletion mutant proteins with the wild type. However, thus far it has not been possible to detect any general alteration in starch and sugar metabolism in mutant plants. In other words, are rescue genes mutant alleles of the genes that normally kill hybrids? The increase in mutant frequency was attributed to an increase in point mutations. This suggests that having two copies of the mutant gene interferes with survival. In 1997, Mitchell proposed a new hypothesis for the bimodal size distribution of mutant colonies. In a nutshell, it involves looking at a mutant line and mapping the mutation to a specific gene. These results are consistent with a loss of one functional copy of the ear gene in the mutant strains. Five of six genes, regardless of X or autosomal location, are increased in expression to a slight degree in mutant females. Only the quadruple mutant lacking all four genes exhibits a complete loss of floral organ identity. To eliminate possible additional mutations, the mutant strains were backcrossed eight times before genetic analyses. The progenitor of the mutant allele was assumed to be the parental allele that was closest in size to the mutant allele. Plus, how often did he get to go on super cool rescue missions in top-secret mutant laboratories? In this mutant, the anterior region of each segment is duplicated in mirror-image polarity, and the posterior region is lost. That imbalance prevents seeds and pollen from developing normally, making the mutant plants sterile. These results are in keeping with our analysis of the polymerase and DNA binding assay for this mutant. There was a clear deficiency of bast fibre along the length of the mutant stem. Such a mutant megagamete could participate in fertilization with wild type pollens and sometimes set aberrant seeds with twin embryos. The mutant protein was immobilized on CNBr-activated Sepharose according to the manufacturer's instruction. Show More Sentences A second class of mutant displays sensory organs in wholly ectopic positions, although these are always separated by epidermal cells. Structures normally found at the nonmutant leaf edge are absent from the affected region of the mutant leaf and leaf homologous organs. The suppression of the mutant phenotype of a1-mum2 aleurones takes several generations. Thus, suppression of the cut mutant wing phenotype is most likely due to the overexpression of Lola. In addition, enhancement or suppression of the H mutant phenotype was evaluated. The rensa mutant produced chlamydospores acrogenously from hyphae or by the modification of hyphal cells, as did the wild type. They noted that the mutant mice groomed themselves excessively-to the extent of creating bald spots and skin wounds. In this mutant, a protein is inactivated which plays a key role during the negative feedback control of chlorophyll biosynthesis. The pumilio mutant exhibits increased rates of long-term facilitation at the larval neuromuscular junction. The sit mutant of tomato accumulates the biologically inactive compound trans ABA alcohol instead of ABA in response to water stress. The preparation of international rugby teams is becoming a hothouse breeding mutant plants. We constructed plasmid fusions by cloning the promoter regions of the wild-type parent and the inversion mutant onto the pRS550 plasmid. It should be mentioned that there is no evidence for disturbed chlorophyll biosynthesis in the mutant. He appoints himself to train them at his mutant academy, which is cleverly disguised as a private boarding school. The killer is hypothesized to be a mutant and should be considered armed and highly dangerous. And then there are the clams themselves, what with their icky clam foot sticking out of their shell like a tongue of a lecherous mutant. The mutant protein in each of these conditions is prone to clump together, forming aggregates, which appear to damage brain tissue. This prompted us to test whether any of these proteins could rescue the mutant insensitivities to pheromone. However, only for a minority of genes is the function defined by a mutant phenotype. A classic forward genetics approach relies on the identification of observable mutant phenotypes. Show More Sentences A relationship between these genes has also been obtained from mutant analysis as well as phylogenetic analysis. They give rise to clones of mutant cells showing up as mosaic spots on the eyes or the wings, respectively. Subsequent genetic crosses showed that only 3 out of 13 new mutant phenotypes were allelic. It is important to realize that mutations in different mutant individuals are not necessarily distinct. These findings raised the possibility that the mutant Ant may form an unselective channel that causes mitochondrial dysfunction and cell death. We established transgenes, allowing conditional expression of the mutant kinase under control of the heat-shock promoter. We conclude that the haploids had a greater frequency of mutant phenotypes than the diploids. To examine germination in various mutant strains, conidial swelling and germ tube emergence were observed under the microscope. The mutant lines also had higher seed weights and grain yields per plant than the parental line. By maturity, the mutant seeds had only produced a few short fibres and the seeds were visible from the mature cotton bolls. In addition, protein metabolism becomes chaotic and disorderly, leading to mutant antibodies becoming auto-antibodies. This indicates that a simple Euclidean distance in feature space can be used to quantify the relative similarity between different mutant types. The mutant did not exhibit any visible sign of fruiting although the parental strain formed fertile fruit bodies constitutively. A female would show an abnormal sex-linked trait at full strength only in the case that she received the same mutant allele from both parents. Section of a bnd clone viewed under light microscopy shows no recognizable photoreceptors or ommatidial organization in the mutant tissue. In addition, binding of the yeast CBF3 kinetochore complex to centromeric DNA was severely compromised in this mutant. There was a hideous mutant running around, horribly mutilating cattle and farmers alike. Despite no or reduced exchange, both mutant alleles have normal synaptonemal complex. They also report the absence of periclinal cell divisions at the base of the mutant awn. All other plants from crosses involving a resistant mutant line were genotyped. Show More Sentences The most common mutant phenotype was an embryo with a polar body near one end and the development of one or two spindles in the middle. The double dagger on chromosome 6 indicates the region that is preferentially homozygous W22 in both mutant and wild-type kernels. This 300-year-old tree was a rare mutant, a sort of arboreal albino that had long been sacred to the native Haida community. We presume this reduction reflects dead cells in the mutant cultures, as noted above. Thus, significant inflorescence and floral meristem activity is restored to stm null mutant plants in the absence of ULT1 function. Those experiments showed that the neural stem cells in the mutant mice developed into the normal lineages of cells in the embryonic brain. By contrast, mutant hermaphrodites are self-sterile when unmated due to a failure in spermatid activation. Moreover, in contrast to wild-type croziers, almost all mutant croziers are uninucleate. An effective vaccine cannot be manufactured yet because a mutant strain of bird flu passing between humans has not been seen. Furthermore, isolated mutant axonemes lacking the central pair or radial spokes can vigorously beat in certain nonphysiological solutions. Suffice it to say, I was steadily engrossed and ultimately moved by a drama that is, in the end, more human than mutant. Take out the launchers as quickly as possible, then wipe out the remaining soldiers and sentinels with your mutant powers. The bithorax phenocopies show a transformation of metathoracic to mesothoracic segments, imitating the Ultrabithorax mutant phenotype. Tufted is a classical Drosophila mutant characterized by a large number of ectopic mechanosensory bristles on the dorsal mesothorax. If they inherited one good copy and one mutant copy they would be carriers of the disease, while remaining healthy themselves. This could involve the expression in a yeast mutant, which is defective for an analogous transport system. On this song, a mutant dancehall pattern bumps to static offbeats and a hiccuping vocal that's an integral part of the groove. White mutant diploid zygospores did not germinate when subjected to low light overnight. The test was internally corrected for differences in reactivity or spontaneous courtship behavior between mutant and wild-type flies. Eight of the mutant alleles have revealing molecular lesions that allowed them to be sorted into four groups. Show More Sentences We constructed eight mutant rhodopsin proteins and studied the effect of arrestin-mediated deactivation. According to the magazine report, new varieties of bananas cannot be easily produced as the plant is a sterile mutant. Initial backcrosses of the third mutant failed and were not reattempted due to findings during complementation testing. This mutant displayed involute leaves and early flowering, although less than clf and icu2 mutants. A study published in the New England Journal of Medicine claimed that the disease is a mutant relative of the common cold. Here we are cajoled into reading adjacent daubs figuratively, as melting body parts or mutant landscapes. Researchers also observed reduced growth or degeneration of the heart and skeletal muscles in mutant mice. We're always wary of giving this mutant form of hate-mongering any more publicity. The dst1-1 mutant regularly developed mature fruiting bodies at the top of dark stipes after a prolonged cultivation. Amplification with both normal and mutant primers indicates the heterozygous deletion of that type. In a recent study of this mutant, results very similar to those of Smith et al. were obtained. The concentrations of chloride, malate, and citrate were also affected in the mutant. All of the taiep rats were the products of a mutant strain bred by our laboratory. A study to reveal the overall structural alteration in this mutant is now in progress. Drug resistance arises by natural selection, mutant strains being selected when the virus replicates in sub-limiting drug concentrations. Just to stop us getting too excited, we were cautioned by stories of eugenics and mutant pigs. The mutant isolation names are included as a part of the description of mutant phenotypes. I've been 19 for over a day now and I haven't shown any signs of growing a third arm or any other mutant abnormality. Mutants that failed to complement known mutant lines were mapped further and the genes were identified from the map position. The judge once dated a psychotically murderous mutant amnesiac. Show More Sentences Sliding into druggy paranoia, Beverly sees mutant women wherever he looks. Ten wild-type females crossed with mutant males gave birth to 22 heterozygous mutant mouse pups and 30 wild-type littermates, which were used as control pups. To rule out cell positioning as a possible cause of fusion failure, the researchers precisely analyzed the arrangements of unfused cells in mutant worms. For nicotinate hydroxylase assays, cnxE strains were first crossed to a mutant in the structural gene encoding xanthine dehydrogenase to generate cnxE hxA1 double mutants. The second mutant phenotype is a slower rate of photoreceptive disk membrane renewal in the outer segments, caused by perturbed phagocytosis of disk membranes. The constant slathering praise directed at the likes of them is the critical equivalent of a one-eyed chinless inbred mutant winning a beauty contest. Grilled flatbread with fresh, roasted figs, a pungent melt of blue cheese and a cap of pleasantly bitter arugula leaves has the appeal of some inspired pizza mutant. Glabrous mutant varieties have been identified in many cereal crop species, including rice, wheat, barley, oats, pearl millet, sugarcane, and sorghum. Evidence of a carotenoid mutant of rice was suggested by the phenotype of several mutants for which viviparous seeds germinated into albino seedlings. By contrast, no linkage was detected in crosses with the five class II mutant strains since phototrophic recombinants were recovered at high frequency. In this mutant the proton pump process is inhibited, and one does not expect to observe a change in the polarizable proton absorption during the photocycle. In lieu of bone marrow transplants, scientists hope to use stem cells to serve as the future vectors of mutant CCR5 proteins. Meiotic spindle poles of mutant embryos are not as well focused as wild type, and meiotic failure often leads to multiple maternal pronuclei as compared to wild type. This can cause broken nerve tracts and might also correct the abnormal lateral positioning of the longitudinal tracts to some extent in these mutant embryos. Does it have a mutant euglena for a sidekick, called Minoxodil? While the purpose of early mutant isolations was mostly focused on the identification of auxotrophs, many of these early strains have been subjected to heavy mutagenesis. A plasmid containing this 3.1 kb of wild-type genomic DNA was cotransfected with a trp1 plasmid into protoplasts isolated from an auxotrophic thn1 mutant strain. The phh1 single mutant is not completely sterile but is nearly sterile, whereas the msa1 deletion mutants conjugated efficiently even in nutrient-rich medium. Harvested bacterial colonies containing mutant plasmids were grown in LB medium in the presence of ampicillin and kanamycin to maintain the selective pressure on the mutants. Representative plates from retests of mutant candidates are shown. Show More Sentences Two lines were unusual in that mutant males regularly produced mosaic progeny that had large patches of somatic tissue lacking the paternal fourth chromosome. Intriguingly, the tensile strengths of the mutant and wild type fibres were very similar which means that decreased coarseness was not achieved at the expense of strength. The mutant also has severely reduced growth rates and a distinctive purple leaf colour as a result of increased anthocyanin pigmentation, particularly when grown in soil. Let me tell you, there's a reason that the mutant monsters in horror films generally come from one of two places, a nuclear waste dump or a sewer. We added 1 ml of ion-supplemented bacterized culture medium to each well of a set of screening plates numbered to match those containing the mutant cell clones. This mutant exhibits lowered activation rates and anticoagulant activity. The complete molecular analysis of the mutant, including the complementation of the mutated gene, is currently being completed and will be reported separately. Transgenic DNA constructs have been used to rescue mutant genes, express reporter genes, and test the relationship of gene structure and function in vivo. The orbicular-shaped mutant leaves are further characterized by the leaf apex, which is retuse in contrast to the acuminate apex of leaves of wild-type plants. These results can be explained by analyzing the mutant trajectories. Expression of the mitochondrial tricarboxylic acid cycle genes also showed little change and those with significant differences in the pho3 mutant were increased. The period length of the double mutant strains was close to values predicted from assuming an additive or multiplicative effect from each mutation. The phenotypic analysis of fru mutant embryos along with fru's temporal and spatial expression pattern suggests that the fru gene functions during axonal outgrowth. At first, I thought it must have been some sort of mutant glow-worm! So even if a group is composed exclusively of altruists, all behaving nicely towards each other, it only takes a single selfish mutant to bring an end to this happy idyll. About 40 wild-type and mutant plants were grown on soil in the greenhouse. The hypothesis was confirmed in experiments using phase-contrast microscopy, which showed the presence of individualized spermatids in the mutant testes. The gene function is known in four cases, based on mutant phenotypes. A causative role for AHA3 in male gametogenesis was proven by complementation with a normal transgenic gene and rescue of the mutant phenotype back to wild type. In these diseases, a single mutant copy of a gene inherited from either parent dominates the normal gene by producing a protein that is toxic to cells. Show More Sentences Of the 230 mutants, 55 fell into the first class and we continued the characterization of 36 of these mutants that had highly penetrant mutant phenotypes. Because of the difficulties associated with performing genetics on partially penetrant mutations, this mutant will not be discussed further in this paper. In mutant form, superbugs can wreak havoc in hospitals and rest homes, infecting open wounds and forcing the closure of wards and operating theatres. However, all of the fitness and morphological traits they reviewed had distributions of mutant effects more leptokurtic than a normal distribution. In all four cases the embryos produced by mutant females had a small number of apparently polyploid nuclei rather than the normal, large number of diploid syncytial nuclei. The mms4 mutant has previously been found to be sensitive to alkylating agents such as MMS, weakly sensitive to ultraviolet light, and resistant to X rays. I helped give birth to the mutant celebrity nightmare that has now eaten the media world. Pairing of homologous chromosomes is confirmed in the mutant strain. Cells from mutant colonies were subcultured daily for at least 5 days. For your gaming pleasure, a whole new assortment of mutant insects have been created including killer roaches, acid-shooting houseflies and fire ants. She fiddles with the child safety cap on one, releases it and pops two pills the size of giant mutant rabbit droppings between lips still smudged with red lippie. Loss of hereditary uterine protoporphyria through chromosomal rearrangement in mutant Rhode Island Red hens. Direct p53 binding followed by conformational changes appears to be a mechanism by which mutant p53 is depleted. Another important finding by researchers is that the double mutant rrrbrb pea line had the most profound reduction in the constituent legumin. Curiously, however, two research groups have found that PPAR-gamma activators increase the incidence of cancer in certain mutant strains of mice. Kinetics of ethanol production by a thermotolerant mutant of Saccharomyces cerevisiae in a microprocessor controlled bioreactor. The invention further provides a method for randomly mutagenizing a gene by amplifying the gene using a low fidelity polymerase mutant. After the initial discovery, the mutants were crossed inter se and pure homozygous stock of the mutant was established. They found that the mutant flies raised with the younger control flies lived twice as long as mutants housed with other mutants. New pre-clinical data demonstrate that ALN-TTR administration is associated with markedly reduced pathogenic deposition of mutant TTR in tissues. Show More Sentences Bactericidal and opsonizing effects of normal serum on mutant strains of Salmonella typhimurium. All carried the mutant gene causing ornithine carbamoyltransferase deficiency, and two of the five subsequently died. The Frasier star is joining the cast of X Men 3 as Beast, a giant, blue-furred mutant monster who is also a pacifist genetics researcher. The mutant strains have a shrinker phenotype which is caused by a mutation in GARA receptors. This parthenocarpic mutant has spun off another opportunity for CSIRO breeders. A rice heterochronic mutant, moril, is defective in the juvenile-adult phase change. Chaperonins play a natural role in reshaping mutant proteins and in keeping newly made proteins from tangling. A wild-type strain, N2, and two mutant strains, unc-46 and unc-25 were characterized. Researchers showed that two DDX3X mutant proteins were unable to tap ATP energy. Scientists have developed a device that filters from blood the mutant proteins that cause the human form of mad cow disease. The brain-wasting diseases BSE, known as mad cow disease, and human CJD are caused by different forms of mutant proteins called prions. This implies that the mutant exchange more slowly with nucleoplasmic pool of free GFP tagged mutant protein than the wild type protein. A cosmid clone, pOK40, which complements the mutant K818, was isolated from a genomic library of the parent strain. Fgfr1 null mutant embryos die during gastrulation and segmentation, while homozygous embryos of Fgfr2 knockout die before gonad formation. A remarkable maize mutant, aberrant phyllotaxy1 displays a decussate phyllotactic pattern while wild type maize develops as distichous plants. An aggressive strain of mutant giant piranhas escape from the River Amazon and head for Florida. We utilize the FLP-FRT technology to generate and select for homozygous mutant germline clones within heterozygotes. When the Shyr mutant was grown on this cloudly medium, there was a clear zone surrounding the colonies. To be an evolutionarily stable strategy, remember, a strategy must not be invadable, when it is common, by a rare mutant strategy. The figs are of a mutant variety that cannot be pollinated by insects, and therefore the trees can only reproduce from cuttings. Show More Sentences In series two, they''re joined by a mechanoid named Kryten and together they battle time distortion, mutant diseases and bizarre life forms. In series two, they're joined by a mechanoid named Kryten and together they battle time distortion, mutant diseases and bizarre life forms. Albino mutant rats were first used for research in 1828 and later became the first animal domesticated for purely scientific purposes. Particularly in the context of disease, the proportion of mutant mtDNA molecules in a cell is termed heteroplasmy. Analysis of the genetic pathway leading to formation of ectopic apical ectodermal ridges in mouse Engrailed-1 mutant limbs. The mutant can be easily distinguished from wild type by the naked eye and requires no extra care for maintenance in the laboratory. Schornack s lab that a mutant of SymRK receptor which is unable to develop mycorrhization show extensive colonization by the root pathogenic oomycete Phytophthora palmivora. Davidson notes that these results are somewhat surprising because this intervention knocks down the mutant proteins by only about 60 percent, making the payoff remarkable. Much to Johnson's surprise, his studies of such mutant mice have led to the identification of the gene responsible for a rare human disorder called nail-patella syndrome. To capture structural snapshots of C3bB and C3bBD, the researchers first generated mutant proteins that would stabilize the complexes in their active forms. Genetic data describing the maize mutant stocks as well as myriad other data about maize genetics can be accessed at MaizeGDB, the Maize Genetics and Genomics Database. Our model revealed that increasing another cell chemical called progranulin reduced the death of neurons by combating the accumulation of the mutant proteins. Early studies of polyQ disease revealed large nuclear inclusion bodies containing proteolytically cleaved mutant protein as a common pathogenic marker. Both mutant strains showed similar growth profiles, displaying higher growth on purines, intermediates of the urea cycle and of the tricarboxylic acid cycle. All malignant tumors harbor genetic alterations, some of which may lead to the production of mutant proteins that are capable of triggering an antitumor immune response. When he falls into a vat of mutant electric eels, he morphs into Electro, a glowing monster who can manipulate electricity and suck the power from a whole city. For the experiment, researchers raised members of a mutant, short-lived species of fruit fly, in a vial with younger members of control fruit flies. To assess the cell wall properties, the effect of isoxaben, an inhibitor of cellulose synthase, on fei1fei2, galt2galt5, sos5, and the quintuple mutant was examined. Here, we introduce an Mtb-selective protein labeling method based on genetic incorporation of azidonorleucine through the expression of a mutant methionyl-tRNA synthetase. Analysis of mosaic animals after mitotic recombination could permit to investigate the phenotype of the mutant clones in wild-type or otherwise mutant imaginal discs. Show More Sentences Whether this man was a mutant or this is a tall story is unclear. Colourless eye, a recessive autosomal mutant of Anopheles stephensi. Simpson DJ, Baquar MR, McGlasson WB and TH Lee Changes in Ultrastructure and pigment content during development and senesce of fruits of nor and rin mutant tomatoes. Examples from Classical Literature That should be enough to tell you about the modern Pasteur and his mutant virus. Breeding experiments show that eosin eye color differs from the red color of the eye of the wild fly by a single mutant factor. In Drosophila a mutant, eosin eye-color, appeared in which the female has darker eyes than the male. Again, a mutant stock in the fruit fly has as its most marked characteristic very short wings. When this mutant first appeared its similarity to arc led us to suspect that it might be arc itself or an allelomorph of arc. They were a mutant breed, gigantic in physical stature, peaceful in nature. Friday's issue of the journal Science described the antibodies as capable of attaching to and neutralizing mutant HIV viruses. He realized that he was in the mutant Quarter, not far from Myla's house. Any tribe led by Deklay would be hostile to the mutant animals. Or the Solar System would be peopled by mutant monstrosities. After transfection of this mutant into 293T cells, we observed no differences in compartmentalization pattern between mutant and wild-type Siva fusion proteins. In contrast, electric current didn't open the mutant channels. Find more words! 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What is the opposite of mutant? Words that rhyme with mutant What is the plural of mutant? What is the adverb for mutant? What is the adjective for mutant? What is the noun for mutant? Translations for mutant Use our Sentence Generator Nearby Words mutandis mutagens mutagenicity mutagenic mutagenesis mutagen mutants mutate mutated mutates mutating mutation 6-letter Words Starting With m mu mut muta mutan