What is another word for flies in the ointment?

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Noun
Difficult or tangled situations
Noun
Situations that require resolution
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“The only fly in the ointment is the project stuff which is so onerous it would ordinarily have had me eating my desk blotter with frustration.”
Noun
Plural for something that ruins or spoils everything else
Noun
Plural for a person or thing whose presence or behaviour is likely to put one at a disadvantage
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