The researchers changed the anticodon in their new tRNA to match up with the UAG stop codon instead of the codon for glutamine. |
To begin with, these trials will concern the exon skipping and stop codon approaches, developed respectively by Prosensa and PTC Therapeutics. |
The start codon appeared at position 77 bp and the stop codon at 1629 bp. |
The mutations identified by the collaboration are found in the next-to-last and last exons of the gene which result in disruption of the reading frame in the first instance and the appearance of a stop codon in the second. |
In transcription and expression studies, sT-Ag terminates at a stop codon within the LT-Ag intron. |
We report 3 cases with 1 homozygous and 2 heterozygous mutations at codon 37 causing a premature stop codon. |