| Gentamicin is an antibiotic that causes the RNA translation mechanism in the ribosomes to ignore such a premature stop codon, i.e. to read through it. |
| We report 3 cases with 1 homozygous and 2 heterozygous mutations at codon 37 causing a premature stop codon. |
| This causes a frame shift in the mRNA and a premature stop codon leading to a truncated and non-functional dystrophin protein which is subsequently degraded in the muscle cells. |
| Introduction of stop codon and consistent inheritance of the mutation with the disorder indicated its pathogenic nature. |
| The researchers changed the anticodon in their new tRNA to match up with the UAG stop codon instead of the codon for glutamine. |
| The start codon appeared at position 77 bp and the stop codon at 1629 bp. |
