| To begin with, these trials will concern the exon skipping and stop codon approaches, developed respectively by Prosensa and PTC Therapeutics. |
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| The mutations identified by the collaboration are found in the next-to-last and last exons of the gene which result in disruption of the reading frame in the first instance and the appearance of a stop codon in the second. |
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| The researchers changed the anticodon in their new tRNA to match up with the UAG stop codon instead of the codon for glutamine. |
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| The start codon appeared at position 77 bp and the stop codon at 1629 bp. |
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| We report 3 cases with 1 homozygous and 2 heterozygous mutations at codon 37 causing a premature stop codon. |
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| In transcription and expression studies, sT-Ag terminates at a stop codon within the LT-Ag intron. |
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| Evidence against either a premature stop codon or the absence of Ob gene mRNA in human obesity. |
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| Introduction of stop codon and consistent inheritance of the mutation with the disorder indicated its pathogenic nature. |
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| Their dystrophin gene has a point mutation in the splice receptor site of intron 6 which leads to the deletion of exon 7 in the mRNA, to a frame shift, and a premature stop codon. |
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| Gentamicin is an antibiotic that causes the RNA translation mechanism in the ribosomes to ignore such a premature stop codon, i.e. to read through it. |
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| This causes a frame shift in the mRNA and a premature stop codon leading to a truncated and non-functional dystrophin protein which is subsequently degraded in the muscle cells. |
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| To determine if 19F NMR can be used to monitor F448 conformation, we will employ amber stop codon technology to replace F448 of SdKef with 4-trifluromethyl-L-phenylalanine. |
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