| When patients receive narcotics for long periods, they can even become more sensitive to pain, a condition called hyperalgesia. |
| These mediators and the related tissue injury prolong pain and hyperalgesia. |
| The mechanism for the pain may involve the development of an area of hyperalgesia as a result of myofascial stretch injury. |
| Neurogenic inflammation is a process by which sensory nerves may secrete inflammatory mediators, resulting in hyperalgesia and inflammation. |
| Intravenous opiates or ketamine administered before incision can lead to decreases in wound hyperalgesia days after the surgery. |
| Prostaglandins promote the development of hyperalgesia by sensitizing nociceptive neurons. |
