| Derailments of the RB-pathway components, cyclin D1 and cdk4 in particular, seems to participate in the endometrial cancer development in humans. |
| In general, cyclins are proteins that regulate the cell cycle by combining with cyclin dependent kinases to form an enzymatic complex. |
| The cells express a protein called cyclin D1 that allows the cancerous cells to propagate. |
| Subsequently it... reappears and disappears every time the cells divide.' Hunt had located a key protein in cell division called a cyclin, another piece in the jigsaw of checkpoint regulation necessary for healthy growth. |
| This pattern of expression suggests that cyclin DI overexpression may be an early event in endometrial carcinogenesis. |
| Here it is important to notice that lack of NFAT5 did not shut down all processes, and for instance NFAT5-deficient cells were able to reinduce cyclin D3 after its initial downregulation by hypertonic stress. |
