| Tyrosine kinases associated with cyclins have also been shown to be affected by vitamin K, which can lead to cell cycle arrest and cell death. |
|
| It is through changes in the production of cyclins during the cell cycle that the activity of the genes controlling it are themselves regulated. |
|
| In general, cyclins are proteins that regulate the cell cycle by combining with cyclin dependent kinases to form an enzymatic complex. |
|
| It has been reported recently that regulated nuclear transport of cyclins and other proteins is required for cell cycle progression. |
|
| Numerous studies from different laboratories have shown an extensive functional overlap between these two cyclins. |
|
| Proteasome degradation of cyclins involved in cell cycle regulation has been well documented. |
|
| It is considered a mechanism that can quantitatively regulate substrates such as cyclins, transcription factors, hormone nuclear receptors, and oncoproteins. |
|
| The patients had stopped all anti-acne treatments: topical for 15 days, cyclins for 30 days and isotretinoin for 6 months. |
|
| This enzyme and others like it link up with proteins called cyclins, and together these molecules push a cell to start dividing. |
|
| Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. |
|
| In his Nobel lecture, Hunt lauded the simple, but brilliant, experiments of Ruderman and Katherine Swenson, who were the first to show that cyclins bring about cell division. |
|
| The accumulation and breakdown of cyclins is an essential step in cell division. |
|
| Hunt's key breakthrough about the cell cycle, the discovery cyclins, centred on his experiments with sea urchins and clams in the Marine Biology Laboratory, Woods Hole. |
|
| I am delighted that the citation of the 2001 Nobel Prize in Medicine pays tribute to the importance of CDKs and cyclins and their role in checkpoint control of cancer cells. |
|
| Cyclins, cyclin-dependent kinases, and tumor suppressor gene products interact and regulate the normal cell cycle. |
|
