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What is a vicissitude?

What is a vicissitude? Here are some definitions.

Noun
  1. Regular change or succession from one thing to another, or one part of a cycle to the next; alternation; mutual succession; interchange.
  2. (plural) A change, especially in one's life or fortunes.
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Examples
Smith's early promise has been compromised by the 49ers' vicissitude, and he and the team have stagnated.
We have to accept the vicissitude sequent on a violated treaty.
Every vicissitude that life can throw at Rembrandt – each pouch and jowl, every newly acquired line – calls for an artistic answer.
The mind craves to make something perdurable out of something as tenuous as candlelight, something that becomes more and more itself through vicissitude.
Psychological origins of the cults to divinity and their inherence in the social vicissitude of the peoples.
Carolina Bagnarol, a former business manager for the rock group Journey who is no stranger to vicissitude, is skeptical.

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