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What are vicissitudes?

What are vicissitudes? Here are some definitions.

Noun
  1. plural of vicissitude
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An eternal optimist, proprietor Robert Finch has an amazing story to tell of the vicissitudes of farming emus.
The notion of freedom was redefined subjectively, as an inner state that can be maintained despite the vicissitudes of political life.
He was a moderate Islamist who was skilled at weathering the vicissitudes of Somali politics.
But something tells me, despite all the vicissitudes, setbacks and struggles of a long career, that she will still be in the pink.
He focused, so to speak, on the pragmatics of the signifier rather than on the vicissitudes of the signified.
It is possible there may have been several vicissitudes of changes wrought upon the same part of the Earth.

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