| First, the titin molecule is composed of a discrete number of globular domains and a nonglobular segment. |
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| In all the experiments on native titin, the molecule was attached to two beads, each labeled with an antibody to a different epitope. |
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| Molecular elasticity is associated with a select number of polypeptides and proteins, such as titin, Lustrin A, silk fibroin, and spider silk dragline protein. |
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| A gene therapy approach was also tested: the trans-splicing of the last exon of titin. |
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| A molecule called Matrix Metalloproteinase-2 cuts titin by acting like molecular scissors. |
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| Our approach is next tested against computer simulations of a multimodule titin model with anharmonic linkers and then applied to experimental data for the unfolding of titin. |
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| Recently it has been suggested that several different regions of titin might play a role in the sensing of stretch in muscle by binding various ligands. |
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| To overcome this problem, we tested an approach which exchanged the last exon or the last exons of the titin messenger. |
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| We were able to demonstrate the correction of titin in vitro. |
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| Titin, however, consists of multiple folded modules connected by short linker peptides. |
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| Titin is a giant protein expressed in both skeletal muscles and heart. |
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