| It is known that induction of telomere shortening leads to the extinction of yeast clones similar to a senescent phenotype. |
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| Such a widespread conservation of telomeric silencing among eukaryotes suggests that it is fundamental to telomere function. |
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| All transfectants lacked detectable telomerase activity, showed progressive telomere shortening and ultimately arrested and died. |
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| This ancestral telomeric element has evolved to optimize telomere maintenance. |
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| Which chromosomes have the shortest telomeres depends only on telomere length in the original parent mice. |
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| These two genes are tightly linked to the left telomere of the X chromosome. |
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| In nature, a chromosome can be lengthened by the enzyme telomerase, which adds new TTAGGG sequences to the end of the telomere. |
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| The telomere analysis method presents the advantage of knowing the ages of a large number of living whales. |
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| Generally, as all the normal cells of a human body go through cell division 50 to 100 times, the telomere is all cut off. |
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| The telomere is but one of the factors in the aging process, and research remains intense in this area. |
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| Another laboratory has revealed the existence of human tumour stem cells exhibiting an atypical form of telomere maintenance. |
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| In some specific inflammatory and immune diseases, telomere attrition may be the critical factor in promoting the development of cancer. |
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| A new and unexpected finding is that the influence of telomere proximity extends to ectopic recombination between homologous sequences located interstitially. |
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| But it's only now that the medical community is closing in on telomere testing for the average patient. |
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| The correlation between paternal lifespan and children's telomere length applied only to daughters. |
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| Not only did counselling stop telomere shrinkage, it actually promoted telomere growth. |
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| With that in mind, the researchers started comparing telomere lengths within families. Tel-talesWhat they found was a bit of a shock. |
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| The telomere, we now know, acts as a sort of molecular clock, allowing a cell to keep track of divisions and hence of its lifespan. |
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| So Dr Epel and her colleagues now want to take measurements over a longer period, to assess the rate of telomere shortening relative to stress. |
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| Several nucleoside-based inhibitors of these viral enzymes, including that of the HIV virus, also typically show modest inhibition of telomere synthesis. |
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| Those born with progeria have short telomere by nature. |
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| In the genetic syndrome dyskeratosis congenita, caused by defects in the telomerase complex, telomere shortening is accelerated, and patients have premature onset of several age-related disorders and early death. |
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| The team's data indicated that there is significant genetic instability in regions near the telomere, the repetitive DNA sequences that protects the ends of chromosomes from damage. |
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| But it is Blackburn's groundbreaking work on telomeric DNA, which launched the field of telomere research, that will have the more profound and long-lasting effect on science and society. |
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| Cardiologists from the University of California, San Francisco, and other hospitals measured telomere length over five years in 608 patients who had coronary-artery blockage and previous heart attacks. |
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| Until recently, there has been no way to test and monitor telomere length over time. |
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| Harley, 58, is a pioneer in telomere research, and a rigorous scientist. |
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| There are two major pathways for telomere elongation in cancer cells. |
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| Data were presented on pre-treatment baseline telomere lengths from fractionated peripheral blood cells for five CLL patients and two solid tumor patients. |
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