| A feature shared by senescent cells in culture and in vivo is shortening of the telomeres. |
|
| In both normal-length and elongated telomeres, telomeric turnover was found to involve all but the innermost few repeats. |
|
| Which chromosomes have the shortest telomeres depends only on telomere length in the original parent mice. |
|
| In normal somatic cells, the telomeres shorten with replicative age, and telomerase is not detected. |
|
| It has long been thought that the grouping of telomeres is important for chromosome pairing and subsequent synapsis. |
|
| If any components of the telomerase are missing, telomeres are gradually shortened and most cells die. |
|
| Several studies show involvement of telomeres in the pairing of homologs during meiosis. |
|
| The region neighboring the telomeres also appears to be rich in duplicated regions. |
|
| Every time a chromosome replicates itself, its telomeres shorten in length. |
|
| Strains with mutations in both genes are very sensitive to DNA damaging agents, have very short telomeres, and undergo cellular senescence. |
|
| In eukaryotic cells with telomeres composed of short tandem repeats, this involves the enzyme telomerase. |
|
| Cancer cells have the ability to divide infinitely and also to preserve their telomeres while escaping erosion. |
|
| Over the past few decades, the study of telomeres has risen to become a white-hot area of very legitimate scientific research. |
|
| Yet telomeres also play a role in uncontrolled cancer growth and metastasis. |
|
| Unfortunately, for this odontocete species the shortening of telomeres does not occur. |
|
| As a result, male birds tend to outlive their mates. A further biological difference between the sexes is in the lengths of their telomeres. |
|
| Men's telomeres are shorter than those of women, and also degrade more quickly. |
|
| Any Canadian researcher working on issues related to telomeres and telomerases is invited to attend this meeting. |
|
| Genetic analysis is then used to determine the length of telomeres contained in the DNA of their cells. |
|
| By altering the length of the telomeres in our transgenic mice, we are already able to prolong their lifespan without impairing their health. |
|
|
|
| Over time, as cells reproduce, our telomeres become shorter and shorter, until they become so stubby that the process stops. |
|
| That life-giving source is the enzyme telomerase, which can actually lengthen telomeres. |
|
| However, tribute should be paid to one man, Joe Gall, a brilliant telomeres biologist at Yale who fought unstintingly for the cause of women. |
|
| Stress reduces the restorative effect of telomeres, decreasing the cell's capacity for self-renewal. |
|
| Results of the study show childhood adversity and lifetime psychopathology were each associated with shorter telomeres and higher mtDNA content. |
|
| At the ends of the linear chromosomes are specialized regions of DNA called telomeres. |
|
| The extremities or arms of a chromosome, called telomeres, naturally shorten each time a cell replicates. |
|
| When telomeres reach critically shortened length and a DNA damage signal is induced, a replicative senescence, or cell ageing, occurs. |
|
| As our telomeres get longer, our lives may get longer. |
|
| Skin cells with telomeres lengthened by the procedure were able to divide up to 40 more times than untreated cells. |
|
| The findings are based on a study of telomeres, protective caps on the ends of chromosomes that shorten as we age. |
|
| Cytocell offers a complete set of liquid subtelomere specific probes identifying 41 of the 46 human subtelomeres with the exclusion of the p-arm telomeres of the acrocentric chromosomes. |
|
| Telomerase is an enzyme that controls the lengths of deoxyribonucleic acid at the ends of chromosomes, called telomeres. |
|
| We also showed that telomeres are at the origin of the development of cancerous somatic cells, which become 'immortalised' when they fail to shorten in the normal way and continue to divide and grow indefinitely. |
|
| Contraction of telomeres together with increased telomerase activity has been described in solid tumours as well as in haematologic malignancies. |
|
| Eventually, the telomeres become too short for division to occur again. |
|
| In 1997, I managed to produce the first telomerase knockout mouse, that is to say, a mouse that is genetically deficient in the production of the telomerase enzyme whose telomeres become shorter each time a cell divides. |
|
| The decisive world influence of women like Blackburn and Greider in telomeres research had helped to dispel the bigotry that all too often propelled men into top science jobs. |
|
| Back then we were only just starting to realise that telomeres provided a unique key to both understanding the ageing process and fighting cancer. |
|
| It has become very interesting to look at what happens to telomeres in humans, because they really do seem to reflect our status of health and our risk of disease in quite a striking way. |
|
|
|
| As we grow older, telomerase is not always active and telomeres shorten. |
|
| Chromosomes carry the human body's genetic information, and telomeres act as buffers, Blackburn said in an interview two years ago with Time magazine. |
|
| Teams are already working to produce a treatment to act on telomeres. |
|
| Claus M. Azzalin, Professor of Biochemistry, received funding for his research into telomeres, an important structural element of DNA which is believed to play a role in ageing processes. |
|
| Stem cell, SENS, gene regulation, mitochondria support, brain uploading, nanomedicine, telomeres, cryonics, and others. |
|
| The researchers also assessed the activity of an enzyme called telomerase, which maintains telomeres. |
|
| Like shoestring aglets, telomeres stop chromosomes from unraveling or being eaten away at the ends. |
|
| Critically, telomeres confer stability to chromosomes by preventing DNA degradation and end-to-end fusion during replication. |
|
| Here are 10 ways you can preserve or lengthen your telomeres. |
|
| Telomere length is considered a biomarker of aging, with shorter telomeres associated with a decreased life expectancy and increased rates of chronic disease development. |
|
| This longevity may be due to telomerase, an enzyme that repairs long repetitive sections of DNA sequences at the ends of chromosomes, referred to as telomeres. |
|
| Telomeres play important roles in genome stability and in maintaining the individuality of linear eukaryotic chromosomes. |
|
| Telomeres and centromeres typically contain few genes but are important for the function and stability of chromosomes. |
|
| Telomeres keep the DNA at the ends of our genes from fraying or sticking together. |
|
| Telomeres are nubby pieces of protein that are attached to the end of chromosomes. |
|
| Telomeres sit on the end of chromosomes, stopping them from fraying and scrambling the genetic codes they contain. |
|
| Telomeres sit on the ends of chromosomes in cells and stop them fraying and your DNA from disintegrating. |
|
| Telomeres are small regions found at the end of chromosomes that shorten as cells within the body replicate. |
|
| Telomeres are repetitive DNA-protein complexes that protect the ends of linear chromosomes and maintain genomic stability. |
|
