| Despite the large increase in enthalpy and entropy, the free energy difference between the closed and open conformations is relatively small. |
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| At some point, increasing error causes major information loss because many conformations populate the average noise sphere. |
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| Analysis of protein loop conformations is a notoriously difficult task because they do not have easily identifiable regular geometric patterns. |
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| Overall, the simulation secondary structure profiles closely resemble those of the crystal conformations. |
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| Together with the associated protein troponin, TM on actin can switch between two laterally shifted conformations. |
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| In both proteins these results suggest the unfolded ensemble of conformations retain a substantial number of rigid substructures. |
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| A given exonuclease hydrolyzes DNA at a fixed rate, but there exist a distribution of conformations and a distribution of hydrolysis rates. |
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| These simulation results suggest that the ensemble that minimizes them spans conformations with different degrees of nativeness. |
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| Then, we fix the adsorbed DNA molecules in their conformations thanks to uranyl acetate and we dry the sample using filter paper. |
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| For example, oxytocin and vasopressin have about a thousand different conformations in solution, all in dynamic equilibrium one with another. |
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| Therefore, the given stiffness values provide an effective description, obtained from sampling many different linker conformations. |
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| The stereochemistry of the model was checked and all residues found to be in allowed conformations. |
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| When dissolved in water, most proteins fold into either a single conformation or a small ensemble of similar conformations. |
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| We then estimate the free energies of all dimer conformations in all-atom molecular mechanics simulations with explicit water. |
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| Amino acid side chains are known to adopt discrete conformations depending on the local protein environment. |
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| It expresses a pre-existing heterogeneity between two or more conformations, which are probably interconvertible in a slow equilibrium process. |
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| The filament is able to adopt many polymorphic conformations, including left-handed and right-handed supercoils, depending on various environmental conditions. |
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| The double-stranded helices are either parallel or antiparallel and exist in a variety of conformations of different lengths and numbers of residues per turn. |
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| Bond lengths and bond angles are held fixed at standard equilibrium values and aromatic moieties are assigned planar conformations unless found otherwise by experiment. |
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| In the contour plot, red indicates the most probable conformations. |
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| It takes different conformations when it is neutral and ionized. |
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| Moreover, the fraction of stacked conformations for a given set of linker dihedrals is consistently greater for the bis-adenyl compounds than for the bis-naphthyl compounds. |
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| At low collision energies, most reflective of nonperturbed conformations, all forms of the protein exist in a single conformational family. |
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| The metal also has a flexible coordination geometry, which allows proteins using it to rapidly shift conformations to perform biological reactions. |
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| Chaperonins not only protect proteins against stress conditions that cause denaturation but also bind to unfolded proteins to help them fold into their active conformations. |
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