How to use conformational in a sentence

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Sentence Examples These conformational changes then modulate interactions with an unknown factor in the signaling pathway. These functions increased the conformational energy of the system if it deviated from specified parameters. In this article, we only study the kinetics involving the conformational changes near the binding interface. The asterisks refer to different conformational states as detected by intrinsic protein fluorescence. The lipid membrane environment influences the conformational space explored by the peptide. These entropic effects are necessary for calculating free energies, which are the true gauges of conformational stability at equilibrium. The anharmonic dynamics involve diffusive motion and allow sampling of different conformational substates. Fluorescence intensity, lifetime, spectral shift, and anisotropy all may be used to monitor conformational changes. Interaction with the receptor of the target cell may be essential for this conformational change and the conformation itself. In some crystal structures, the conformational changes are limited to local residues surrounding the Schiff base. The authors found that the protein undergoes a larger conformational change when assembled onto a nanoparticle having a larger diameter. They separated the DNA out of the blood and analyzed it with conformational gel electrophoresis. Such a mixing of configurations is present in proteins, where the energy of the excited state is dissipated among many conformational substates. Single monomers undergo conformational changes in the course of the simulation. This choice was made to maximize the functional conformational differences between the two states. This conformational changing process is strengthened by the increase in the affinity of the enzyme and for its coenzymes during hibernation. Our results suggest that on UV irradiation, arginine can induce certain conformational alterations in DNA rendering it immunogenic. In this approach, only energy-minimized conformational substates have been considered. Our team is also interested in selecting antibodies sensitive to conformational changes or to post-translational modifications. Interestingly, the monomolecular two-state model considered for DNA condensation resembles the models for ligand-induced protein conformational transition. Show More Sentences These studies distinguish the conformational and colligative properties of the individual bases in DNA and their inherent capacity to promote specific folding pathways. This phenomenon of interface activation was originally detected in studies on porcine pancreatic lipase and was attributed to a conformational change. All those recent results suggest a flexibility of the backbone conformational structure and several stable configurations are proposed and debated. The most significant contributions derive from the conformational degrees of freedom of the chain, its vibrational modes, and the hydration of the chemical groups. These conformational changes increase the separation of the glycosidic oxygen atoms and therefore are favored in polysaccharide chains subjected to mechanical stretching. With their centers of mass remaining unchanged the monomers shift away from the starting structure into different directions in conformational space. Can similar conformational transitions occur in vivo, for example, during exocytotic swelling of secretory granules or in a stretched fibronectin matrix? Multi-scale theory for self-assembly and conformational stability of supramolecular nanoarchitectures in solution. Because the interconversion of the two tautomers is slower than the actual proton transfer reaction, a conformational change is probably associated with the isomerization. In contrast, hydrophobic driven binding and low levels of electrostatic interactions are associated with conformational flexibility and cross-reactivity. In addition, conformational changes may not occur to the same extent as in solution because they could be limited by intermolecular contacts in the crystal lattice. The first category is directed against conformational epitopes associated with the native doublehelical structure. The result of this interaction is that ARC blocks Bax conformational activation and translocation to the mitochondria during apoptosis. Another interesting mechanism defining specificity deals with conformational stability of the binding site. This modification leads a conformational change of the protein which results in a blue fluorescence. The overall conformational energy of a molecular system is presented as the sum of van-der-Waals interactions, electrostatic interactions, and torsion energies. A molecular beacon recognizes the target DNA and undergoes a conformational change. Coverage and conformational ordering of self-assembled monolayer of alkanethiolate have been assessed with a sub-femtomole detection limit by micro-FTIR using a grazing angle objective. These conformational isomeric species have different receptibility towards agostic interaction. The interaction of the target protein with Adlyfe's proprietary peptides produces a conformational change that transduces a fluorescent signal. Show More Sentences In particular, we investigate genetic defects that leads to the misfolfing and improper targeting of GPCRs and result in pathologies known as conformational diseases. The Monte Carlo minimization approach to investigate conformational space is used in predicting ligand-binding modes and refining modeled protein structures. However, when they hybridise to a nucleic acid strand containing a target sequence they undergo a conformational change that enables them to fluoresce. Isobutane has no conformational isomers, but butane is closely analogous to 1,2-dideuterioethane, in that a pair of anti and gauche conformational isomers is possible for that molecule. This internal spacer provided a conformational rigidity to the macrocycle. This time there is no imaginable rotation about bonds that can equilibrate the two isomers, so these two molecules are not conformational isomers. It is thought that the resting, activated, and inactivated states of the sodium channel are due to voltage-dependent conformational changes in the glycoprotein component. As with many organic molecules, there are possibilities for conformational isomerism due to internal hydrogen bonding within the molecule. The conformational epitopes for anti-ß2GPI develop when it interacts with a lipid membrane composed of negatively charged phospholipids or when ß2GPI is adsorbed on a polyoxygenated polystyrene plate. In other conformational states, they can block the passage of ions. The most important difference between a membrane channel and the glucose transporter is the conformational change that the transporter undergoes while moving glucose across the membrane. This overall reaction, completing the cycle of conformational changes in the enzyme, involves a strict coupling of the splitting of ATP with the pumping of sodium and potassium. If the injury is linked to a conformational fault, the fault is likely to be passed to the next generation. At low collision energies, most reflective of nonperturbed conformations, all forms of the protein exist in a single conformational family. The research should establish in detail the conformational control of the sialic acid residue on type III group B Streptococcus polysaccharide. Recent studies provide data on the molecular characteristics and conformational properties of three cereal beta-glucans. Direct p53 binding followed by conformational changes appears to be a mechanism by which mutant p53 is depleted. Still other methods omit bisulphite treatment entirely, such as single-stranded conformational analysis. Phototransduction involves a conformational change in the chromophore and activation of an opsin. Membrane potential-dependent conformational changes in mitochondrially bound hexokinase of brain. Show More Sentences Introduced in 1989, the concept of conformal dimension has proven useful in areas including conformational dynamics, geometric function theory, and geometric group theory. In order to explain these results, the Quantum Theory of Atoms in Molecules is used to examine the conformational behavior of the chloroacetate anion at the atomic level. Some researchers presume the photoreaction may be the basis of conformational changes that occur in the protein, which is a possible mode of protein interaction. His research interests include conformational analysis, computational aspects of combinatorial chemistry, ligand-protein interactions, and medicinal chemistry. Approaches to the conformational analysis of biopharmaceuticals. Find more words! 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What is the adjective for conformational? What is the noun for conformational? Use our Sentence Generator Nearby Words conformation conformance conformally conformal conformably conformable conformations conformed conformers conforming conformism conformist 14-letter Words Starting With c co con conf confo confor conform conforma conformat conformati conformatio