| Hence, it is clear that not a general anti-apoptotic effect but rather a more specific mechanism underlies this irresponsiveness to antifolates. |
| We propose that EBV protein Zta activates SOCS3 protein as an immune escape mechanism that both suppresses optimal IFNα secretion by human monocytes and favors a state of type I IFN irresponsiveness in these cells. |
| Despite such irresponsiveness, regular reminders were made for them to take part in the audit process. |
| Both Nora and Frank assume Tommy's irresponsiveness means he doesn't take anything in. |
| In all cases hypotonia, irresponsiveness and irritability were present in the neonatal period. |
| The second issue concerned the causes of different patterns of state irresponsiveness to care needs in Nicaragua and India. |
