| The irresponsiveness of hNPCs toward AhR modulation was hence likely due to very low AhR expression combined with a human low-affinity receptor for ligand binding. |
| Hence, it is clear that not a general anti-apoptotic effect but rather a more specific mechanism underlies this irresponsiveness to antifolates. |
| In all cases hypotonia, irresponsiveness and irritability were present in the neonatal period. |
| Hence, atypical presentation of hip or low back pain and its irresponsiveness to anti-inflammatory medication warrants further investigation. |
| We propose that EBV protein Zta activates SOCS3 protein as an immune escape mechanism that both suppresses optimal IFNα secretion by human monocytes and favors a state of type I IFN irresponsiveness in these cells. |
| The second issue concerned the causes of different patterns of state irresponsiveness to care needs in Nicaragua and India. |
