The role of cerebro-spinal hypocretin measurement in the diagnostic of narcolepsy and other hypersomnias. |
It seems to be caused by a deficiency of hypocretin, a molecule that allows cells to successfully communicate with each other. |
Human narcolepsy generally stems from a shortage of the neurons, which produce the excitatory neurotransmitter known both as hypocretin and orexin. |
The narcoleptic brains showed a dramatic loss of hypocretin cells, between 85 and 95 percent fewer than the normal brains. |
Research has identified that there is reduced hypocretin in the brains of those who have narcolepsy. |
Gliosis is linked to neuronal degeneration and may explain the loss of the hypocretin cells. |