Other researchers found that hypocretin has a negative feedback relationship with GABA and a positive feedback relationship with the excitatory neurotransmitter glutamate. |
Human narcolepsy generally stems from a shortage of the neurons, which produce the excitatory neurotransmitter known both as hypocretin and orexin. |
Gliosis is linked to neuronal degeneration and may explain the loss of the hypocretin cells. |
It seems to be caused by a deficiency of hypocretin, a molecule that allows cells to successfully communicate with each other. |
Hypocretin activation and synaptic innervation of the locus coeruleus noradrenergic system. |
Research has identified that there is reduced hypocretin in the brains of those who have narcolepsy. |