| The microbe was sensitive only to a drug called colistin, which had been developed decades earlier and largely abandoned as a systemic treatment, because it can severely damage the kidneys. |
| Antimicrobial agents, colistin and nalidixic acid, suppress growth of gram-negative organisms. |
| Chinese scientists have discovered a gene in bacteria that conveys resistance to colistin, a drug presently used in humans when other antibiotics won't work but also used on a large scale in pig farms. |
| However, CRE isolate data did not contain information on susceptibility to other CRE treatment options, including colistin, tigecycline, polymyxin B, and fosfomycin. |
| The form available in South Africa is a prodrug, colistimethate sodium or colistin methanesulfonate, which makes a bolus dose necessary to achieve therapeutic effect. |
| Last-line polymyxin drugs such as polymyxin B and colistin have been used for 60-70 years without developing a significant resistance. |
