| Antimicrobial agents, colistin and nalidixic acid, suppress growth of gram-negative organisms. |
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| The microbe was sensitive only to a drug called colistin, which had been developed decades earlier and largely abandoned as a systemic treatment, because it can severely damage the kidneys. |
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| Chinese scientists have discovered a gene in bacteria that conveys resistance to colistin, a drug presently used in humans when other antibiotics won't work but also used on a large scale in pig farms. |
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| Last-line polymyxin drugs such as polymyxin B and colistin have been used for 60-70 years without developing a significant resistance. |
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| However, CRE isolate data did not contain information on susceptibility to other CRE treatment options, including colistin, tigecycline, polymyxin B, and fosfomycin. |
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| The form available in South Africa is a prodrug, colistimethate sodium or colistin methanesulfonate, which makes a bolus dose necessary to achieve therapeutic effect. |
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| Colistin, also known as polymyxin E, is a cationic lipopeptide antibiotic isolated from Bacillus polymyxa subsp. |
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| Synereca's lead program involves compounds that potentiate the effectiveness of Colistin without enhancing toxicity. |
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