| This alkaloid inhibited AChE in the same fashion as some AD drugs including donepezil, tacrine and rivastigmine which are noncompetitive inhibitors. |
| Monitoring of serum transaminase levels is recommended with use of tacrine because of potential hepatotoxicity. |
| The cholinesterase inhibitor tacrine is used rarely because of potential liver toxicity and the need for frequent laboratory monitoring. |
| These effects are comparable to those of the drug tacrine, which is prescribed for Alzheimer's disease. |
| The pharmacologic characteristics and side effects of tacrine make it a second-line agent. |
| There have been no direct comparison studies to tacrine or donepezil. |
