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What is tacrine?

What is tacrine? Here are some definitions.

  1. A parasympathomimetic anticholinesterase, one of the first approved for the treatment of Alzheimer's disease.
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The cholinesterase inhibitor tacrine is used rarely because of potential liver toxicity and the need for frequent laboratory monitoring.
Monitoring of serum transaminase levels is recommended with use of tacrine because of potential hepatotoxicity.
There have been no direct comparison studies to tacrine or donepezil.
These effects are comparable to those of the drug tacrine, which is prescribed for Alzheimer's disease.
This alkaloid inhibited AChE in the same fashion as some AD drugs including donepezil, tacrine and rivastigmine which are noncompetitive inhibitors.
The pharmacologic characteristics and side effects of tacrine make it a second-line agent.

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