| Many antidepressants inhibit serotonin or norepinephrine reuptake or both to achieve their clinical effect. |
| Cocaine acts by inhibiting norepinephrine reuptake in peripheral sympathetic nerve terminals as well as stimulating central sympathetic outflow. |
| Serotonin is a vasoconstrictor and uses agonists, such as ADP, epinephrine, and norepinephrine, to promote platelet aggregation. |
| In addition to their effects as neurotransmitters, norepinephrine and epinephrine can influence the rate of metabolism. |
| This adrenaline rush is an effect caused by the adrenal glands in the body manufacturing epinephrine, cortisol, and norepinephrine. |
| The second mechanism of TCA cardiotoxicity involves the blockade of norepinephrine uptake at the adrenergic presynaptic endings. |
