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What does substitutions mean?

Looking for the meaning or definition of the word substitutions? Here's what it means.

Noun
  1. plural of substitution
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Half of the amino acid substitutions were nonconservative changes for different properties such as charge, polarity, and volume.
Flavonoids are plant derivatives of flavone with various degrees of hydroxylation and glycosidic substitutions.
In the second half, play was constantly disrupted by both sides making a number of substitutions.
At half time Army made five substitutions to rest some key player and give some experience to some new players.
The British Council has also stepped into this arena, with analysis of the impact of substitutions on the results of football games.
He also developed a widely used correction for multiple undetected changes in evolutionary base substitutions.

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