This sequence along with its immediate flanking sequences were used to generate a hammerhead ribozyme according to the Haseloff and Gerlach model. |
A vector comprising a procaryotic promoter system and a ribozyme fused to a stable E. coli RNA gene which comprises from about 50 to 200 nucleotides. |
Those positions located in the catalytic core of the ribozyme are shown in italicized boldface type. |
The plan is to use ribozyme to decrease the APP gene expression. |
Ribozyme Pharmaceuticals Inc., Boulder, Colo., 3.2 million shares. |
Of these, only the hammerhead ribozyme form is in clinical trials as it offers advantages in manufacturing techniques. |