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What is refractoriness?

What is refractoriness? Here are some definitions.

Noun
  1. The quality of being refractory.
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Examples
Patients in the study had already demonstrated refractoriness to physical therapy.
Pure clay base is also highly resistant to fire and therefore contributes to the refractoriness of the mass.
This refractoriness varies in every species of animal in its relation to every form of germ.
He is willing to hope you to be all obedience, and would prevent all incitements to refractoriness.
Platelet alloantibodies are responsible for neonatal alloimmune thrombocytopenia and platelet refractoriness.
Since all resistance is useless, I lay down my arms although after relapses into refractoriness.

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