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What is pathogenesis?

What is pathogenesis? Here are some definitions.

Noun
  1. The origin and development of a disease.
  2. The mechanism whereby something causes a disease.
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Examples
Numerous cytokines and growth factors have been implicated as mediators in the pathogenesis of pulmonary fibrosis.
Its pathogenesis is thought to involve cone and amacrine cell dysfunction in the retina.
Although the exact cause of acne is unclear, its pathogenesis involves many factors that are interrelated.
This provides strong support for the mesothelial cell dislodgment theory of pathogenesis for mesothelial cell aggregates within lymph nodes.
There is broad consensus that cognitive deficits play a crucial role for both the pathogenesis and prognosis of schizophrenic psychoses.
There was even less of a clue with regard to their implication in the pathogenesis of rheumatic fever and glomerulonephritis.

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