| Minimal skeletal hyperostosis and calcification of tendons have also been observed by x-rays in prospective studies of cystic acne patients treated with a single course of therapy at recommended doses. |
| Computed tomography scan of the sternoclavicular joints revealed hyperostosis and erosions involving the sternum as well as medial end of clavicle. |
| Bone changes including, premature epiphyseal closure, hyperostosis and calcification of tendons and ligaments have occurred after several years of administration at high doses for treating disorders of keratinization. |
| These changes can also be seen in fibrous dysplasia, hyperparathyroidism, giant-cell tumor, and infantile cortical hyperostosis. |
| Additionally, skeletal hyperostosis was noted in six of eight patients in a prospective study of disorders of keratinization. |
| When there is hyperostosis and sclerosis, the shaft appears denser and broader than normal, and the contour is uneven or wavy. |
