| If the hyperbilirubinemia is not treated promptly, these infants become hypertonic and may develop a fever and a high-pitched cry. |
| The occurrence of severe hyperbilirubinemia mandates an investigation of the cause of hyperbilirubinemia. |
| Furthermore, clinical assessment of jaundice is inadequate for diagnosing hyperbilirubinemia. |
| Critical hyperbilirubinemia is uncommon but has the potential for causing long-term neurological impairment. |
| Abnormal hemorrhage, hyperbilirubinemia and oliguria are late findings. |
| An infant who presents with severe hyperbilirubinemia or who progresses to severe hyperbilirubinemia despite initial treatment should receive immediate intensive phototherapy. |
