| Conjugated hyperbilirubinemia also may result from problems that occur after the bilirubin is conjugated in the liver. |
| Bilirubin accumulates in the body when the excretion of bilirubin in the bile cannot keep up with production. |
| Normally, the liver processes this bilirubin and excretes it into the bowel through the bile duct. |
| The breakdown of porphyrin yields bilirubin, a product that is non-polar and therefore, insoluble. |
| In the liver, to which is transported in the plasma bound to albumin, bilirubin is solubilized by conjugation to glucuronate. |
| It means the liver cannot break down bilirubin, which can leave the sufferer jaundiced and lead to brain damage. |
