How to use bilirubin in a sentence

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Sentence Examples At physiologic pH, bilirubin is insoluble in plasma and requires protein binding with albumin. The body eliminates bilirubin by transporting it to the liver bound to albumin in the serum. The liver plays an essential role in the metabolism of bilirubin and the excretion of its metabolites into the bile. It could be observed whether bilirubin, haemoglobin or lactescence of the samples interfere with the measurement procedure. Normally, the liver processes this bilirubin and excretes it into the bowel through the bile duct. Patients presenting with obstructive jaundice show increases in serum bilirubin, alkaline phosphatase, and glutamyl transferase. A healthy liver filters bilirubin, a breakdown product of old red blood cells. Precipitated bilirubin may form a nidus for subsequent cholesterol deposition. It means the liver cannot break down bilirubin, which can leave the sufferer jaundiced and lead to brain damage. In prehepatic jaundice, excess unconjugated bilirubin is produced faster than the liver is able to conjugate it for excretion. In infants found to be clinically jaundiced during the first 2-3 days, it is helpful to document the rate of rise in the serum bilirubin level. When the liver becomes congested, serum transaminase and bilirubin levels may become elevated, and jaundice may be present. Blood tests showed raised levels of aspartate transaminase, alkaline phosphatase and bilirubin, confirming liver damage. The breakdown of porphyrin yields bilirubin, a product that is non-polar and therefore, insoluble. We have studied the effect of indican on six commercial procedures for the measurement of total bilirubin in serum. In the liver, to which is transported in the plasma bound to albumin, bilirubin is solubilized by conjugation to glucuronate. Bilirubin accumulates in the body when the excretion of bilirubin in the bile cannot keep up with production. Conjugated hyperbilirubinemia also may result from problems that occur after the bilirubin is conjugated in the liver. It is possible to measure bilirubin concentration using capillary or venous blood samples or transcutaneously. The combination of blue and white lights with optimised outputs provides accelerated reduction of high levels of serum bilirubin. Show More Sentences The authors conclude that it is not necessary to keep infants in the hospital to check for rebound serum bilirubin levels in infants treated with phototherapy. With reduced enteral feeding, the enterohepatic circulation of bilirubin is greatly increased. The bilirubin concentration causing kernicterus varies depending on the brain's vulnerability to bilirubin's neurotoxic effects. There was no significant difference between the early and late groups in bilirubin levels and proportions of infants receiving phototherapy. The sample required an average of 49 phototherapy hours each to achieve the bilirubin discharge level. During the acute phase of bilirubin encephalopathy, these infants are noted to be lethargic and hypotonic, with a poor sucking reflex. Blue light is particularly good at helping the body break down bilirubin, which causes the condition. Kernicterus, severe brain damage caused by an abnormal concentration of the bile pigment bilirubin in brain tissues at or shortly after birth. If your baby's liver is immature at birth, the extra red blood cells and bilirubin stay in the body, making the skin look yellow. After delivery, your baby's liver breaks down and disposes of the extra cells, leaving a waste product called bilirubin. In hepatocytes, UDP glucuronyl transferase adds 2 equivalents of glucuronic acid to bilirubin to produce the more water soluble, bilirubin diglucuronide derivative. Destruction of these cells releases haem from their haemoglobin, which is quickly metabolized in the liver to biliverdin and, in turn, to bilirubin. Subsequent transaminase and bilirubin measurements in 1989, 1996 and 1997 were all within normal limits. Such specimens may be used by instrument manufacturers as standards for calibrating bilirubin methods and for assigning values to calibrators provided to instrument users. The Dräger Jaundice Meter JM-103 is a hand-held transcutaneous bilirubin meter that provides an objective index of icterus in infants. Using a spectral reflectance technique to measure transcutaneous bilirubin in neonates: a new device. Kernicterus describes the neuropathologic changes resulting from deposits of unconjugated bilirubin in the basal ganglia nuclei. Who should have their bilirubin concentration measured, when and by what method? Jaundice in babies is the result of a temporary accumulation of the bile pigment bilirubin. Recent reports of increasing kernicterus have led to further discussion regarding the level of bilirubin considered detrimental to the otherwise healthy term neonate, whose jaundice is not attributable to hemolysis. Show More Sentences The protein gets its glow on by connecting with the pigment bilirubin, scientists report in the June 20 Cell. In Gilbert's syndrome, there is a reduced level of the chemical that deals with the bilirubin. Discussion of jaundice requires familiarity with the normal pathways for production and elimination of bilirubin in the body. Heme oxygenase degrades the heme to release iron, carbon monoxide, and biliverdin, and the latter is reduced to bilirubin. It is made by enzymes breaking down the red haem molecule into green biliverdin and yellow bilirubin molecules. The Dräger PT 4000 emits most of its light where the blue portion of the light spectrum is most effective in decomposing bilirubin at an absorption peak of 460 nm. Transaminases and bilirubin levels over the next six days decreased towards normal levels and the patient was subsequently discharged home. Decreased urobilinogen was also observed and is considered to be related to changes in the intestinal flora resulting in reduced production of urobilinogen from bilirubin. Hepatic function should be assessed biochemically with INR, albumin, and bilirubin, and clinically with the presence or absence of ascites, encephalopathy, and portal hypertension. Additional safety endpoints included major and minor bleeding events, intracranial bleeding, intracerebral haemorrhage, elevations in liver transaminases, bilirubin and hepatic dysfunction. Abnormal laboratory tests were reported including positive Coombs test, elevated bilirubin, elevated LDH, pancytopenia, neutropenia and agranulocytosis. Indican indoxyl sulfate can produce a yellow-orange to red colour response, which may interfere with the interpretation of negative or positive bilirubin readings. Some siderophages may contain hematoidin or bilirubin crystals, which are golden-yellow rectangular crystals. Alternative antiretroviral therapy to REYATAZ may be considered if jaundice or scleral icterus associated with bilirubin elevations present cosmetic concerns for patients. Because of a possible transient rise in transaminase and bilirubin values, blood for baseline clinical chemistries should be obtained before RIFATER dosing. Use of a styrene-divinylbenzene copolymer resin for the manufacture of the biomedical device according to claim 8 for the extracorporeal removal of bilirubin and bile acids and derivatives thereof from human blood and plasma. Elevation of SGOT, LDH, alkaline phosphatase and bilirubin with or without frank jaundice, have been reported in the postoperative period following isoflurane anesthesia in some patients. When the rate of red cell destruction exceeds the capacity of the liver to handle bilirubin, the yellow pigment accumulates in the blood, causing jaundice. If the bile duct is blocked, then bile may build up and a substance in the bile called bilirubin may cause jaundice, which leads to yellow skin and eyes. Bile contains a pigment called bilirubin that causes the yellow colour. Show More Sentences The passing of bilirubin via bile through the intestinal tract gives mammalian feces a distinctive brown coloration. However, in a hypoalbuminemic, acidotic newborn, such as a premature infant, this may occur at a much lower serum bilirubin concentration. Deconjugation and reabsorption of some bilirubin for enterohepatic recirculation. For many years, the bile pigment bilirubin was considered a toxic waste product formed during heme catabolism. Do not subtract direct reacting or conjugated bilirubin. Bile principally consists of two bile salts, taurocholic acid and chenodeoxycholic acid, as well as bilirubin. A portion of bilirubin is converted to urobilinogen in the intestine and eventually gets excreted into the urine and feces. The patient's condition improved over days 5 and 6, with total bilirubin and haptoglobin returning to normal levels. Emphasis should be given in excluding other etiologies of elevated bilirubin and transaminases, such as acute hepatitis A, B or C, HIV or other less common viral hepatitides. Convert bilirubin to urobilinogen, some of which is reabsorbed and subjected to enterohepatic recirculation, while the rest is excreted through the kidneys as urobilin. These markers included reticulocyte count, LDL, and indirect bilirubin. In the follow-up CT images, cholangiectasis improved markedly after biliary tract reconstruction, with declines in serum total bilirubin and direct bilirubin. You'll be allowed to take your baby out of the incubator for feeding, but otherwise they'll continue phototherapy until blood tests show that bilirubin levels are normal. Examples from Classical Literature The modern view of hmatogenous jaundice had its origin in the supposed discovery of the identity of hmatoidin with bilirubin. It may assume a greenish hue after standing, owing to oxidation of bilirubin into biliverdin. The union of bilirubin and lime salts illustrates the same principle. Find more words! 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Words that rhyme with bilirubin What is the plural of bilirubin? What is the noun for bilirubin? Use our Sentence Generator Nearby Words biliousness biliously bilious bilinguals bilingually bilingualism bilirubinuria biliteral biliterate biliverdin bilk bilked 9-letter Words Starting With b bi bil bili bilir biliru bilirub bilirubi