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What is a fly in the ointment?

What is a fly in the ointment? Here are some definitions.

Noun
  1. (idiomatic) Something which ruins or spoils everything else; a nuisance or problem; an unpleasant or disagreeable detail.
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Examples
Yes, don't you know I'm going to throw a fly in the ointment?
This evening, I would like, at the outset, to point out a fly in the ointment.
Painting by Huyghe changes from a well-wisher into a fly in the ointment or even worse, to a prophet of doom.
There is, of course, one fly in the ointment, and that is the fact that space exploration costs money.
The only fly in the ointment today was Gentle Annie, a nasty hill.
The only fly in the ointment is the project stuff which is so onerous it would ordinarily have had me eating my desk blotter with frustration.

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