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What does derange mean?

Looking for the meaning or definition of the word derange? Here's what it means.

Verb
  1. (transitive, chiefly passive) To cause (someone) to go insane or become deranged.
  2. (transitive) To cause disorder in (something); to distort from its ideal state.
  3. (archaic) to disrupt somebody's plans, to inconvenience someone
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Examples
It even went so far as to derange all my habits, and to break in, among the rest, upon my opium taking.
Several drugs have been shown to derange macrophage functions, bactericidal efficacy and production and secretion of cytokines.
Let us suppose a special Sedative to derange the action of the vagus nerve.
This does not derange the numbers, since the order of succession is observed.
It has been asked, in what way do you suppose that the affections of a mother should operate to derange the members of the ftus?
Unforeseen accidents may derange our most profound schemes of policy.

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