| They dedifferentiate initially in culture, but later reexpress stable characteristics of mature chondrocytes. |
| Others claim that there are no such reserve cells and that the blastema develops from formerly specialized cells near the wound that dedifferentiate to give rise to the blastema cells. |
| In human hearts, too, Dr. Murry said, the muscle cells dedifferentiate after injury and double up their DNA, a necessary precursor to cell division. |
| Wounding the plant prompts adjacent cells to dedifferentiate, reverting to their stem cell state, in order to heal the wound. |
| By manipulating niche signals, they could make the stem cells differentiate, then dedifferentiate again. |
| A third approach is to use one's own specialized cells and dedifferentiate them. |
