| In the isolated, perfused rabbit heart, dolasetron and its reduced metabolite were equipotent in blocking the positive chronotropic effect of serotonin. |
| Arrhythmogenic and negative chronotropic and dromotropic effects were observed, as well as extension of atrioventricular conduction times. |
| Failure of the heart rate to increase as expected, a condition called chronotropic incompetence, is associated with an increased risk of death from heart disease, a study by the Cleveland Clinic Foundation showed. |
| This is referred to as chronotropic incompetence, which would have implications for intense training and endurance-related activities. |
| Opioids mediate their chronotropic action through an effect on vagal efferents from the central nervous system. |
| Reserpine pre-treatment did not influence the positive chronotropic effect of pentoxifylline in rats. |
