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What does anaplasia mean?

Looking for the meaning or definition of the word anaplasia? Here's what it means.

Noun
  1. (biology) A reversion of differentiation in cells that is characteristic of malignancy in tumours
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Neoplastic cells showed a high degree of anaplasia, high nucleus-to-cytoplasm ratio, usually one prominent nucleolus, partially condensed chromatin, and high mitotic index.
The benign nature of this lesion was suggested by the lack of any mitotic activity, anaplasia, or dysplasia.
We theorize that tumor anaplasia caused malignant myocytes to reexpress CK-MB and cTnT isoforms.
Microscopically, the tumor cells were arranged in diffuse compact trabeculae, with variable degrees of anaplasia, and increased mitotic activity in the control group.
Anaplasia is a loss of visible differentiation that can occur in advanced cancer.
Cancer cells also tend to be less-well-differentiated than normal cells, a characteristic that is called anaplasia.

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