| These data validate mangosteen as an abundant natural source of potent aldose reductase inhibitors. |
| Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy. |
| Inhibition of aldose reductases from rat and bovine lenses by flavonoids. |
| The aldose reductase inhibitory effects of the compounds were determined, and 3-isomangostin was found to be the most active against the enzyme when tested in vitro. |
| The polyol pathway uses the enzyme aldose reductase to convert glucose to sorbitol. |
| Normal mice gained weight and developed fatty liver and insulin resistance, but mice lacking aldose reductase showed less weight gain and less-severe related conditions. |
