| They can act as real enzymes and, by analogy to protein enzymes, are called ribozymes. |
|
| The vesicles were immobilized on supported bilayers and single-molecule analysis was performed for DNA molecules and hairpin ribozymes. |
|
| They placed the DNA copy between two ribozymes, RNA molecules that have enzymatic function and can cleave RNA sequence at specific locations. |
|
| Gene therapy is also making use of catalytic RNA through the construction of ribozymes. |
|
| We therefore encapsulated hairpin ribozymes inside 200-nm vesicles to test for surface effects. |
|
| This view has been strengthened by the discovery that some forms of RNA, called ribozymes, can act like non-protein enzymes to catalyze biological reactions. |
|
| At that time, everyone thought of proteins as the only kind of enzymes and ribozymes had not yet been found. |
|
| Each of these ribozymes and a corresponding non-catalytic control ribozyme was cloned into the shuttle vector, pPCR-Script. |
|
| But to do their work, ribozymes need to first get into the cells, and for that they need help. |
|
| Hammerhead ribozymes are small, catalytic RNAs that can be designed to target and cleave substrate RNAs at sequence specific sites. |
|
| Naturally occurring ribozymes may be used in chemotherapy, but they are large, expensive, and fragile RNA molecules. |
|
