| The term proto-oncogene was coined to distinguish the normal gene from its altered form. |
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| Another mechanism by which a proto-oncogene can be transformed into an oncogene is point mutation. |
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| A proto-oncogene may be converted into an oncogene through a single alteration of a nucleotide. |
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| Data support that its activation and signalling play a role in the pathogenesis of human cancer and it has been recognized as a proto-oncogene. |
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| Proto-oncogene tyrosine-protein kinase 1. proto-oncogene B-Raf. |
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| Beta-1 integrin is a potential proto-oncogene, a gene that activates another gene that causes cancer. |
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| The CD 117 protein is located in the cell membrane of all cells expressing the kit proto-oncogene. |
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| Though it normally help cells mature, c-jun can also act as a proto-oncogene, Timblin explains. |
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| The Genentech researchers validated 392 somatic SNVs in coding regions, including one in the KRAS proto-oncogene. |
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| The src gene, then, was really a cellular oncogene, or proto-oncogene. |
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| However, although such vectors thus show à priori higher levels of security, they are still capable of potential insertion near a proto-oncogene. |
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| Further investigation showed that the vector had inserted the gene near a proto-oncogene, which led to uncontrolled growth of the T cells. The clinical trials were put on hold until a safer method can be designed and tested. |
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| Approximately 25 per cent of all MTC cases are genetic in nature, caused by a mutation in the RET proto-oncogene. |
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| The RET proto-oncogene encodes a cell membrane receptor tyrosine kinase. |
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| A complex comprising a HGF ligand and met proto-oncogene receptor protein wherein said complex is free of protein with which it is naturally associated. |
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| Amplification of the N-MYC proto-oncogene is seen in about 40 percent of cases of neuroblastoma, a tumour of the sympathetic nervous system that commonly occurs in children. |
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| For example, a proto-oncogene becomes a cancer-causing oncogene when mutated in a manner that increases the cell's propensity to divide excessively. |
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