How to use inhibitors in a sentence

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Sentence Examples When those rust inhibitors lose their effectiveness, the inside of the radiator can start to corrode. Legal rules may well be used presentationally, rather than being operational working rules or inhibitors. Endostatin and angiostatin are natural inhibitors of angiogenesis that have been shown to inhibit the growth of a number of human malignancies. We previously reported that ACE inhibitors may cure symptomless dysphagia in hypertensive patients with stroke. Selective serotonin reuptake inhibitors are widely used in clinical practice, and have advanced the treatment of depression. Genetic screens have successfully identified a number of different growth promoters and growth inhibitors in Drosophila. For the first time, we observe that the acyl binding site of cholesterol esterase shows stereospecificity for diastereomeric inhibitors. They commissioned a study of the possible military uses of calmative pharmaceuticals such as anesthetics and serotonin reuptake inhibitors. For this reason, the synthetic hormones are technically known as ovulation inhibitors. But in spite of these inhibitors, there is a promising development around intelligent switches. Production was not abrogated by inhibitors of cyclooxygenases, xanthine oxidase, nitric oxide synthases, and mitochondrial enzymes. These inhibitors can potentiate the hypotensive effects of nitrates and alpha blockers. Other possible inhibitors are unusual fixatives, such as B5 or any solution containing picric acid. Acetylcholine esterase inhibitors such as pyridostigmine offer symptom relief in myasthenia gravis. Blueberries also contain folic acid, ellagic acid, and bacterial inhibitors. Among the drugs most widely employed used to lower blood pressure are the angiotensin converting enzyme inhibitors. Treatments that have been studied but that show no clear benefit include atropine, glucagon, calcitonin and protease inhibitors. The tort threat and the threat of criminal prosecution after a crime has been committed are the most reliable inhibitors of criminal aggression. A group of estrogen-blocking drugs called aromatase inhibitors have proven effective in preventing breast cancer from recurring after surgery. Davis worries that inhibitors of mucus secretion might block activity of beneficial proteins. Show More Sentences Patients could carry PKC inhibitors and take them preventively, as soon as they sense a manic episode coming on. Dropout rates were similar for monotherapy and double therapy but significantly higher in trials containing protease inhibitors. Certain salts, such as the dichromates, borates, and silicates, act as inhibitors to the aqueous corrosion of zinc. The B genes act as awn inhibitors, A acts as awn promotors, b 1 a leads to half awned condition and Hd gives hooded condition. Researchers are investigating whether aromatase inhibitors can prevent breast cancer. Enzyme inhibitors traditionally target the active site by matching its steric, hydrogen binding, and charge constraints. The inhibition of proteinases by protein proteinase inhibitors is an individual case of protein-protein interaction. The most commonly prescribed antidepressant medications include the tricyclics and selective serotonin reuptake inhibitors. Anti-freeze must be changed every two years due to the deterioration of the corrosion inhibitors. Thicker hexagonally shaped ice crystals indicate a higher concentration of ice-growth inhibitors. These inhibitors are small proteins found in many plant seeds such as beans, a food regularly eaten by humans. Corrosion inhibitors protect metal equipment and piping from the effect of prolonged contact with water. Protein synthesis inhibitors can rapidly block translation elongation and cause release of truncated polypeptide chains. Selective serotonin reuptake inhibitors have even been promoted and used as lifestyle drugs. The use of antidepressants, antipsychotics, or anticholinesterase inhibitors for insomnia related to delirium or dementia is also unproved. Early studies in yeast demonstrated selenate and chromate as effective inhibitors of sulfate uptake. Ginseng should not be used with monoamine oxidase inhibitors, stimulants, or anticoagulants. Moreover, inhibition of the cysteine protease activity by chemical inhibitors suppressed the leaf senescence process. The substituted alanines used as inhibitors can be regarded as both analogues of the substrates and the products. The majority of chemotherapeutic strategies have, therefore, focused on the development of retroviral enzyme inhibitors. Show More Sentences Leukotriene inhibitors and leukotriene-receptor antagonists are effective in the treatment of inflammatory diseases such as asthma. Alkaline cleaning is used to remove oils, inhibitors, lubricants and dirt prior to coating. Cr compounds are used industrially as catalysts, corrosion inhibitors and as an alloying metal in making stainless steel and various superalloys. When required, cells were pretreated with various inhibitors before irradiation, and then the medium with and without inhibitors was collected. The underlying mechanisms by which angiotensin converting enzyme inhibitors prevent vascular events have been discussed widely. We restricted our analyses to loop diuretics, angiotensin converting enzyme inhibitors, blockers, spironolactone, and digoxin. There is a need to develop specific inhibitors that target the protease active site. Medicines called ACE inhibitors and angiotensin-II receptor blockers are helpful. Biocides, coagulants, and corrosion inhibitors are the leading products used in the petroleum market. Why don't they just get to the point and start making dopamine reuptake inhibitors? Would they be addictive? But in the end these elements only really came into play in the final episode and they weren't really inhibitors. For example, ACE inhibitors, beta-blockers, ARBs, spironolactone and digoxin are probably not necessary in all patients. High affinity dopamine reuptake inhibitors as potential cocaine antagonists: a strategy for drug development. Recommended drugs for heart failure include ACE inhibitors, beta blockers, and diuretics. Aromatase inhibitors are drugs that reduce the levels of estrogen in your body. The local anesthetics procaine and tetracaine are known inhibitors of excitation-contraction coupling in frog skeletal muscle. Engineered for a life of sea and sun its construction incorporates high calibre flame retardants, UV inhibitors, colourfast pigments and bacteriostats. Therapeutic trials include those with proton pump inhibitors, prokinetic agents, mucosal protectants, anticholinergics and low-dose antidepressants. For HIV, though, real therapy began only 18 years ago with the introduction of a class of drugs, the protease inhibitors. The clastogenicity of topoisomerase inhibitors is believed to result from the transient stabilization of the topoisomerase enzyme with DNA during the catalytic cycle. Show More Sentences This lag could explain the degradation observed in samples from crude lysates produced by these lysis methods even in the presence of RNase inhibitors. It has developed proprietary monoclonal antibodies to properdin that are potent in vitro and in vivo inhibitors of the complement alternative pathway. In order to start the clinical phases for the HIV fusion inhibitors compounds, the company requires a technological partner with expertise in galenic peptide. Medical management consists of maintenance therapy with anticholinergic inhibitors such as pyridostigmine to relieve symptoms and steroids to treat the autoimmunity. Aromatase inhibitors reduce estrogen levels in a woman's body by preventing an enzyme called aromatase from converting other hormones to estrogen. Most scientists working with the new inhibitors and monoclonal antibody treatments acknowledge they will be used in combination with chemotherapy for years yet. Perhaps motorcycles should be compulsorily fitted with speed inhibitors. Dithiols were better reversal agents than monothiols, further suggesting that these inhibitors bind to the proposed vicinal sulfhydryls present on this enzyme. Specific genotypic mutations in the protease gene can result in high levels of phenotype resistance to individual protease inhibitors and cross resistance. Whether the chemical is alcohol, narcotics, cocaine, or nth-generation selective serotonin reuptake inhibitors, their effects tend to become blunted over time. This literature mainly comprises the variation in genes for blood coagulation factors, inhibitors, fibrinolytic factors and platelet membrane receptors. Several nucleoside-based inhibitors of these viral enzymes, including that of the HIV virus, also typically show modest inhibition of telomere synthesis. The normal physiological role for mesotrypsin is surmised to be to digestively degrade naturally occurring trypsin inhibitors found in food such as soybeans. Progress has been made in the development of new anti-emetic drugs, particularly the serotonin antagonists which are potent inhibitors of chemotherapy-induced vomiting. The use of ACE inhibitors to block the breakdown of bradykinin also promotes vasodilation, natriuresis, and a beneficial effect on cardiac remodeling. Cholinesterase inhibitors act by blocking an enzyme that breaks down acetylcholine. Fortunately, degradative bands were not observed, although we did not use protease inhibitors. The new patent application is based on the ability of HDAC6 inhibitors to influence mechanisms both inside and outside of the cell nucleus. Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice. In summary, oligoamides have been shown to be less potent PPI inhibitors than the terphenyl scaffolds. Show More Sentences The discovery that cantharidin inhibits PP5, has led to further research of Protein Phosphatase 5 inhibitors. Selective serotonin reuptake inhibitors are the mainstay of pharmacological treatment for both depression and anxiety disorders. That combination of reverse transcriptase and protease inhibitors works against the virus inside the target cell. There is wide variation across England in who gets cholinesterase inhibitors, such as donepezil, rivastigmine and galantamine, it showed. According to research, these drugs, known as ACE inhibitors, could even boost brain power. Cathepsins B, H, L, their inhibitors stefn A and cystatin C in sera of melanoma patients. Treatment is aimed at reducing GER through dietary modification, proton-pump inhibitors, and prokinetic drugs. There is hypercalciuria, although the risk of renal stones is not increased as inhibitors of stone formation also increase. Other glaucoma medications available include alpha-adrenergic receptor agonists and carbonic anhydrase inhibitors. The ACE inhibitors that do not cross the blood-brain barrier are enalapril, benazepril, moexipril, and quinapril. Design, synthesis and biological evaluation of 4-benzamidobenzoic acid hydrazide derivatives as novel soluble epoxide hydrolase inhibitors. This is the first agent in a new class of antifungals, the echinocandins or glucan synthesis inhibitors, to be approved. Specialty fuel additives include deposit control agents, corrosion inhibitors, antioxidants, antiknock agents, metal deactivators and others. TheraGenetics will undertake a pharmacogenetic study of Alzheimer's patients treated with cholinesterase inhibitors in the study. Indole alkaloids of Psychotria as multifunctional cholinesterases and monoamine oxidases inhibitors. While Prezista was designed to overcome viral resistance to other protease inhibitors, resistance to the drug itself can develop. The compound, systemin, activates or turns on genes that produce two proteinase inhibitors. Using inhibitors to the members of MAPK and PIKK, we also determined the protein kinases responsible for asbestos-induced p53 phosphorylation. The division is also developing naphthoquinones as inhibitors of cell proliferation. Comparative inactivation of isepamicin, amikacin, and gentamicin by nine beta-lactam and two beta-lactamase inhibitors, cilastatin and heparin. Show More Sentences However, like most of our interventions, treatment with proton pump inhibitors has not only benefits but also potential complications. Proton pump inhibitors, which work to stop the backflow of stomach acid, are being overprescribed, they said. But I never addressed the joint and muscle pain that often accompanies the use of aromatase inhibitors. Such reductions were subsequently confirmed in trials testing the other two potent aromatase inhibitors, letrozole and exemestane. The anodic passivators discussed here refer to inhibitors that enhance chemisorption of dissolved oxygen and migrate readily to the anodic sites. Your article on the controversy surrounding selective serotonin reuptake inhibitors is very much appreciated by many people. Schiff bases of ethylenediamine as corrosion inhibitors of zinc in sulphuric acid. However, the seeds contain many kinds of anti-nutritional factors such as lectin, trypsin inhibitors, phytates, and tannins. Known as neuraminidase inhibitors, they can potentially treat all strains of the virus. Selective phosphodiesterase inhibitors such as roflumilast are not registered for use in acute asthma. Challenges of power, size, ruggedization and heat capacity remain key inhibitors to their effective, practical and safe use. While VEGF inhibitors such as bevacizumab provide valuable treatment options, these benefits are not seen in all patients and cancer types. Fetopathy associated with exposure to angiotensin converting enzyme inhibitors and angiotensin receptor antagonists. Treatment with MAO-B inhibitors, which are embryotoxic and fetotoxic at high doses in animals, should be avoided during pregnancy. The inhibitors are typically not consumed during the silicone cure and are expected to volatilize from the cured silicone. Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors. This drug does not have a lot of the toxicities including insulin resistance that have tainted protease inhibitors so far. It is well known that 9-cis and all-trans retinoic acid function as potent inducers of cell differentiation and inhibitors of cell proliferation. In our experiments we identified hexanol, and a related odor, butanal, as strong inhibitors of CO2-sensitive neurons in Culex mosquitoes. Verapamil and selective serotonin-reuptake inhibitors also were widely used, but the reviewers concluded that there was poor evidence of benefit. Show More Sentences The effect of three cyclo-oxygenase inhibitors on intensity of primary dysmenorrhoeic pain. Phosphodiesterase inhibitors pentoxifylline and rolipram, increase bone mass mainly by promoting bone formation in normal mice. Veratrum alkaloids and distal inhibitors of cholesterol biosynthesis are teratogens that have been associated with holoprosencephaly. Mice treated for five days with one of two JAK inhibitors sprouted new hair within 10 days, greatly accelerating the hair follicle growth phase. The cetane improvers segment is growing at a greater pace, followed by the corrosion inhibitors and deposit control additives segments. The arrival of CETP inhibitors is expected to begin in 2018 with the launch of anacetrapib. Blood pressure effects are likely to be drug specific, as other CETP inhibitors in development haven't thus far shown similar problems. Hydrolysis products of glucosinolates in Brassica napus tissues as inhibitors of seed germination. With the advent of targeted therapy, specific tyrosine kinase inhibitors have been developed against the Ableson oncogene. We included GLP-1 mimetics, DPP4 inhibitors and TZDs, along with metformin, since those classes have no potential for hypoglycemia. Other options include selective serotonin reuptake inhibitors and selective noradrenergic reuptake inhibitors. These authors suggested that the AChE inhibitors in nutgrass could possibly act as the plants' defense against herbivores. Several PP1 and PP2A inhibitors, such as okadaic acid, nodularin, and microcystin-LR, are classified as tumor promoters. Phenelzine and tranylcypromine are irreversible inhibitors of the monoamine oxidase enzyme. Rationally designed selective inhibitors of trypanothione reductase phenothiazines and related tricyclics as lead structures. Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors. The recent IN inhibitors, raltegravir and elvitegravir, belong to the latter class of compounds. In vitro comparative assessment of IbetaHactamase inhibitors and their penicillin combinations against selected enterobacteria. For those who used the highest dose of proton pump inhibitors, the risk of deficiency was nearly double that of those who didn't use the drugs. Proton pump inhibitors are among the most widely prescribed medications in the US and worldwide. Show More Sentences Ezetimibe is the first in the new class of cholesterol absorption inhibitors. Patients treated with TNF inhibitors may acquire coccidiomycosis infection through fomite dust exposure. Prescription proton pump inhibitors include esomeprazole, dexlansoprazole, omeprazole, lansoprazole, pantoprazole, and rabeprazole. Therefore, inhibitors, such as phenothiazine, hydroquinone, and hydroquinone mono methyl ether, are commonly used to prevent polymerization. They were comprised of proteinase and its inhibitors, antimicrobial peptides, lectin, and others. In collaboration with Merck, MethylGene is developing small molecule beta-lactamase inhibitors to overcome antibiotic resistance. For some experiments, DCs were incubated with biopharmacological inhibitors to various molecules. A recent high-throughput screen identified various compounds such as PI3K or BCL2 inhibitors that can be combined favorably with ibrutinib. Its advice to primary care on prescribing drugs such as proton pump inhibitors has been criticised as wasteful. Since 2011, doctors sometimes added in the viral inhibitors boceprevir or telaprevir. A new standard of care has emerged with the regulatory approval of the protease inhibitors boceprevir and telaprevir. These data validate mangosteen as an abundant natural source of potent aldose reductase inhibitors. There is also controversy over the use of muzzles and other inhibitors, which prevent the dolphins from foraging for food while working. Urease inhibitors are used to slow the hydrolytic conversion of urea into ammonia, which is prone to evaporation as well as nitrification. Systemin activates defensive mechanisms, such as the production of protease inhibitors to slow the growth of insects. While several classes of kinase inhibitors are highly selective many possess a vast polypharmacology across the kinome target-scape. The mixture contains harmine, harmaline, and tetrahydroharmine, alkaloids that are also MAO inhibitors. Histone deacetylase inhibitors in development include valproic acid, vorinostat, belinostat, panobinostat, entinostat, and romidepsin. The most potent inhibitors are found in potatoes, and of these the most active component is the glycoalkaloid solanine. Forty caregivers were recruited, a majority of whom had a child with hemophilia A without inhibitors. Show More Sentences A study of mice with high blood pressure found that ACE inhibitors were only effective when taken just before sleep. Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists for preventing the progression of diabetic kidney disease. Screening of Zulu medicinal plants for angiotensin converting enzyme inhibitors. Rowland et al have suggested guidelines for managing cardiovascular risks prior to and during treatment with acetylcholinesterase inhibitors. Its mode of action is different from alkalinizing agents such as antacids or histamine-2 receptor blockers and also proton pump inhibitors. Adding low doses of certain selective serotonin reuptake inhibitors enhances the anorexiant effect. In the treatment of PCH, strategies include drugs such as, indomethacin, carbonic anhydrase inhibitors and procedures that may lower intracranial pressure. The dipeptidyl peptidase-IV inhibitors are the newer drugs linked to the most potentially serious side effects, namely, drug-induced bullous pemphigoid and angioedema. Two other classes of drugs that act on the renin-angiotensin system, angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers. Among both groups, nearly half used high blood-pressure medications, such as calcium channel blockers, ACE inhibitors, angiotensin II antagonists and beta blockers. The authors consider it unfortunate that angio-oedema is not listed as a compelling contraindication to ACE inhibitors in the latest South African Hypertension Guidelines. All patients who have received DBS had stage 5 TRD, which meant that their depression was unresponsive to all possible drug classes, including monamine oxidase inhibitors. In a large population-based study, researchers found that the long-term use of proton pump inhibitors was associated with increased risk of vitamin B12 deficiency. Three aryl ureas proved to be potent in vitro inhibitors for all enzymes tested, whereas the screened carbamates and thiocarbamates were poor inhibitors. Sulfate and phosphate ions are competitive inhibitors of sulfatases. Among the some 200 new or revised monographs are ones on buspirone, linezolid, didanosine, ribavirin, dronedarone, protease inhibitors, and oxycodone and rifamcyins. Structure-based optimization of cyclopropyl urea derivatives as potent soluble epoxide hydrolase inhibitors for potential decrease of renal injury without hypotensive action. The 24-hour intraesophageal pH did not normalize in 25 of 50 patients treated with proton pump inhibitors for complete control of gastroesophageal reflux disease. Marine varnish has UV inhibitors to slow down peeling and fading. Phenex is the first company worldwide to have discovered inhibitors for RORgt which show high effectivity in ablating the pro-inflammatory TH17 response. Show More Sentences Secondly, we did not consider the influence of other neuropsychiatric symptoms and neuropsychotropic drugs such as neuroleptics, SSRIs, SNRIs, and cholinesterase inhibitors. Several ALDH inhibitors have been used to cause massive acetaldehyde accumulation after alcohol consumption, most commonly disulfiram and cyanamide. Vitamin-K antagonists, such as warfarin, act differently to direct thrombin inhibitors by interfering with the cyclic interconversion of vitamin K and its 2,3 epoxide. The overall use of antidepressants and the use of selective serotonin reuptake inhibitors increased sharply from 1996 to 2004, when both trends plateaued. The urokinase plasminogen activator system consists of serine protease uPA, two endogenous inhibitors of PAI-1 as well as PAI-2 and uPA receptors. Avian leucocytic responses induced by stress and corticoid inhibitors. Quinine sulphate, piperazine, caffine, barbitone and pyridine derivatives have been used as corrosion inhibitors for aluminium and zinc in acidic medium. The risk for nephrotoxicity may increase when ENVARSUS XR is concomitantly administered with CYP3A inhibitors or drugs associated with nephrotoxicity. Unfortunately, like ACE inhibitors, ARBs may cause hyperkalemia, which may lead to diarrhea, muscle cramps and joint aches and, thus, more sleep disturbances. The new study, which analysed pooled data from nine clinical trials involving 31,920 women, looked at the effect on death rates of taking aromatase inhibitors for five years. Telaprevir and Boceprevir are protease inhibitors which belong to a class of agents known as DAA's, and are the two products currently in phase three development. Besides oseltamivir, other neuraminidase inhibitors are zanamivir, which is inhaled, and the intravenously administered investigational drug peramivir. ProScript is pioneering the use of small molecule inhibitors that target a key protein degradation pathway in cells known as the ubiquitin-proteasome pathway. In patients in whom allopurinol toxicity occurs, options include other xanthine oxidase inhibitors, a uricosuric agent, or allopurinol desensitisation. This alkaloid inhibited AChE in the same fashion as some AD drugs including donepezil, tacrine and rivastigmine which are noncompetitive inhibitors. Nucleoside analog reverse transcriptase inhibitors, the first antiretroviral agents to be introduced to the market back in 1987, remain a mainstay of anti-HIV therapy. The MPP group offers an extensive portfolio of biocides, bactericides, fungicides, mildewcides, algaecides, preservatives and corrosion inhibitors. Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses. Using the phytoforensic approach of accounting for every peak, we have found other compounds like phentolamine and dapoxetine in combination with PDE-5 inhibitors. Thermal processing of soy milk destroys biologically active anti-nutritional components of soybean like trypsin inhibitors, urease, hemagglutinins, goitrogens and saponins. Show More Sentences Anterior cingulate gyrus overactivity causes water retention and decreased gut motility leading to constipation, but is ameliorated by selective serotonin reuptake inhibitors. The Turf product line includes surfactants, well completion and work-over chemicals, bactericides, scale inhibitors, antifoams, paraffin inhibitors and water clarifiers. Such obstacles prompted the development of small chemical inhibitors to dissect biological pathways in an approach popularly known as chemical genomics. Several novel chemotherapeutics that target specific signaling pathways are now available as anti-cancer agents including EGFR inhibitors and rapamycin. Plants that were treated with P450 inhibitors or cloquintocet, but not topramezone were analyzed separately and compared to the non-treated control. Other tyrosine kinase inhibitors are evaluated as well, of which the Syk inhibitors, fostamatinib and entospletinib, might be of particular interest in the near future. By contrast, the CETP inhibitors like evacetrapib are taken orally. Finally, through a complex process of interactions, connective tissues utilize nutrients to repair damage as MMP inhibitors help dissipate inflammation. Targeted therapeutics offer superior pharmacological benefits due to which profit margin of tyrosine kinase inhibitors are expected to increase in coming years. Although at other time points DDE did not raise ERK activation levels above basal, the addition of inhibitors nevertheless did lower activity to subbasal levels. Similar to BRAF and MEK inhibitors, ganetespib effectively suppressed the activity of ERK kinase in melanoma cells, a critical component in the BRAF signaling cascade. A single dose of tenofovir and emtricitabine at delivery reduced resistance to nonnucleoside reverse transcriptase inhibitors at 6 weeks after delivery by half. The finding that the natural phytomolecule luteolin can act as a SphK2 inhibitor may have implications in this field, and in developing this class of inhibitors. Examples from Classical Literature The plants Chinese skullcap and ginger can stop infections there, as they are hemagglutinin inhibitors. Growth of the water treatment market is expected to boost demand for corrosion inhibitors. If tricyclics do not help, MAO inhibitors are usually tried. The 15 N-terminal amino acid sequences had some resemblance to those other of protease inhibitors and inhibitor precursors from leguminous plants. He and colleagues argue that diuretics, ACE inhibitors, and digoxin should be used as soon as a patient is diagnosed as suffering from heart failure. The first generation of MAO inhibitors was characterized by a lack of selectivity in their MAO inhibition, inhibiting both MAO-A and MAO-B with serious side-effects. Find more words! 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What is the opposite of inhibitors? Words that rhyme with inhibitors What is the adverb for inhibitors? What is the adjective for inhibitors? What is the noun for inhibitors? Use our Sentence Generator Nearby Words inhibitor inhibitive inhibitions inhibition inhibiting inhibited inhibitory inhibits in high spirits in hindsight in his absence in his mind's eye 10-letter Words Starting With i in inh inhi inhib inhibi inhibit inhibito inhibitor