| The causes of osteoporosis in men include hypogonadism, glucocorticoid excess, medications and lifestyle factors. |
|
| This confidence cannot be extrapolated to other situations of much larger glucocorticoid exposures in the perinatal period. |
|
| Receptors for corticotropin and the glucocorticoid hormones have been cloned and mechanisms of action elucidated. |
|
| Excessive amounts of glucocorticoid hormones in the body can lead to Cushing syndrome. |
|
| Withdrawal of glucocorticoids may result in symptoms of the glucocorticoid withdrawal syndrome including: fever, myalgia, arthralgia and malaise. |
|
| Addison's disease affects both glucocorticoid and mineralocorticoid function. |
|
| It has a slight but definite glucocorticoid activity and a very slight mineralocorticoid action. |
|
| Clobetasol, an analogue of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity. |
|
| Potentiation of undesirable glucocorticoid effects on the stomach is possible. |
|
| But too much glucocorticoid is a bad thing, so there is also a way to switch off its production. |
|
| For example, a 9α-fluorine atom enhances the glucocorticoid activity of cortisol about 10-fold but its salt-retaining activity about 50-fold. |
|
| This is not unexpected since rabbits are known to be particularly sensitive to glucocorticoid treatment. |
|
| In particular, glucocorticoid effects on memory consolidation require them to act on the amygdala. |
|
| These observed changes are the expected response to glucocorticoid therapy. |
|
| Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. |
|
| In one of them, Dallman and her colleagues simulated chronic stress by increasing the brain concentration of a rodent version of the glucocorticoid called cortisol. |
|
| As glucocorticoid levels rise again at the end of the hyporesponsive period, granule cell proliferation diminishes once again. |
|
| Haematological and biochemical parameters were typical of glucocorticoid overdosage and consisted of a moderate to marked leukopenia and lymphopenia and increased erythrocytes, serum enzymes, protein and cholesterol. |
|
| Microscopic pathology was again consistent with the administration of a potent glucocorticoid showing thymic and adrenal atrophy, lymphoid depletion in rats and dogs and glycogenic vacuolation of the liver in dogs. |
|
| The anti-inflammatory and glucocorticoid activities of cortisol are enhanced, in some cases with relative reduction of its mineralocorticoid activity, by various structural modifications. |
|
|
|
| Effect of glucocorticoid replacement therapy on glucose tolerance and intermediary metabolites in hypopituitary adults. |
|
| Specifically, we looked at the combination of BaP with a glucocorticoid, an organophosphate pesticide, and nicotine. |
|
| Eplerenone had an affinity for mineralocorticoid receptors, and had no measurable activity on estrogen, progesterone, and glucocorticoid receptors. |
|
| The symptoms of glucocorticoid overdose may include confusion, anxiety, depression, gastrointestinal cramping or bleeding, ecchymosis, moon face and hypertension. |
|
| Inhalation studies in the dog resulted in clinical signs associated with the administration of a potent glucocorticoid and consistent with the symptoms of Canine Cushing's Syndrome. |
|
| If after long-term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually, rather than abruptly, to avoid glucocorticoid withdrawal syndrome. |
|
| If mineralocorticoid replacement is necessary, fludrocortisone, a potent mineralocorticoid with minimal glucocorticoid effect, is prescribed. |
|
| Leucopenia, thrombocytopenia and mild anaemia may be present and eosinopenia occurs secondary to glucocorticoid action. |
|
| When glucocorticoid binds to its receptor in the hippocampus, that activates the expression of genes which dampen further synthesis of the hormone. |
|
| Based on data with another glucocorticoid metabolized by CYP3A4, coadministration with ritonavir is not recommended because of the risk of systemic effects secondary to increased exposure to fluticasone furoate. |
|
| Sebaldt RJ, Sheller JR, Oates JA, et al Inhibition of eicosanoid biosynthesis by glucocorticoid in humans. |
|
| The impact of glucocorticoid hormones on lipoprotein metabolism can be examined in normal variation, acute and chronic dosing, replacement therapy, and hypercortisolism. |
|
| Herein, we present an infant with a segmental hemangioma and marked glucocorticoid toxicity due to prior steroid therapy that was successfully treated with propranolol. |
|
| Additionally, patients treated for hypoadrenalism with glucocorticoid therapy may require an increased dose when somatropin is added to their regimen. |
|
| An increasing body of evidence shows that some patients who require corticoids to remedy their asthma are resistant to high-dose glucocorticoid treatment. |
|
| The cellular site of binding of dexamethasone by specific glucocorticoid receptors in cultured hepatoma cells was investigated with the use of certain mercurials. |
|
| The glucocorticoid receptor gene NR3C1 has been widely studied in other inflammatory and autoimmune diseases, such as cystic fibrosis, asthma, and Graves ophthalmopathy. |
|
| However, patients with critical inflammatory diseases, such as serious asthma and chronic obstructive pulmonary disease, appear to be resistant to glucocorticoid treatment. |
|
| It is characterized by hyperkalemia and low levels of plasma renin activity and aldosterone without significant changes in glucocorticoid secretion. |
|
| Glucocorticoid secretion occurs in a circadian pattern and in response to stress. |
|
